Enhanced Anticancer Effect of Green Synthesized Nanogold On Different Cell Lines
faid, A., sharaky, M., Ramadan, M. (2023). Enhanced Anticancer Effect of Green Synthesized Nanogold On Different Cell Lines. EKB Journal Management System, 6(2), 80-91. doi: 10.21608/ijasri.2023.242424.1010
amna H. faid; marwa sharaky; marwa A. Ramadan. "Enhanced Anticancer Effect of Green Synthesized Nanogold On Different Cell Lines". EKB Journal Management System, 6, 2, 2023, 80-91. doi: 10.21608/ijasri.2023.242424.1010
faid, A., sharaky, M., Ramadan, M. (2023). 'Enhanced Anticancer Effect of Green Synthesized Nanogold On Different Cell Lines', EKB Journal Management System, 6(2), pp. 80-91. doi: 10.21608/ijasri.2023.242424.1010
faid, A., sharaky, M., Ramadan, M. Enhanced Anticancer Effect of Green Synthesized Nanogold On Different Cell Lines. EKB Journal Management System, 2023; 6(2): 80-91. doi: 10.21608/ijasri.2023.242424.1010

Enhanced Anticancer Effect of Green Synthesized Nanogold On Different Cell Lines

International Journal of Advanced Scientific Research and Innovation
Volume 6, Issue 2, December 2023, Page 80-91  XML PDF (1.16 MB)
Document Type: Original Article
DOI: 10.21608/ijasri.2023.242424.1010
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Authors
amna H. faid email 1; marwa sharaky2; marwa A. Ramadan3
1Department of laser science and interaction, National Institute for Laser Enhanced Science (NILES) Cairo University, Egypt.
2Cancer Biology Department, National Cancer Institute (NCI), Cairo University, Cairo, Egypt.
3Department of laser application in metrology, photochemistry and agriculture, National Institute for Laser Enhanced Science (NILES) Cairo University (CU), Egypt.
Abstract
Cancer is important cause of mortality, due to difficulty in finding safe, economical and specific effective therapeutic targets. The aim was to investigate the cytotoxicity of hybrid gold-chitosan nanospheres (Au@CsNs) on different cell lines using chitosan. Au@CsNs were analyzed by Zeta potential, UV-Visible spectroscopy, TEM and FTIR. Absorbance at 522 nm correlated to surface plasmon resonance (SPR) of AuNPs. TEM images show that Au@CsNs are spherical, with an average size of 12 ± 2 nm. Results of DPSS (diode pumped solid-state) laser irradiation show the photothermal laser stability of Au@CsNs. Au@CsNs showed anticancer effect using SRP assay on different cancer cell lines HCT, FADU, H460, and HEPG2. Our results suggest that Au@CsNs have an antiproliferative effect as there were a significant decrease in cell viability but this depends on the type of cancer cell line. In conclusion, Au@CsNs exhibited great anticancer activity subsequently it will be used in drug delivery and photothermal therapy in future work.
Keywords
Green Synthesis; Chitosan-coated Gold Nanoparticles; Cancer cells and Laser photostability
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