Enhanced Anticancer Effect of Green Synthesized Nanogold On Different Cell Lines | ||
| International Journal of Advanced Scientific Research and Innovation | ||
| Volume 6, Issue 2, December 2023, Pages 80-91 PDF (1.16 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ijasri.2023.242424.1010 | ||
| Authors | ||
| amna H. faid* 1; marwa sharaky2; marwa A. Ramadan3 | ||
| 1Department of laser science and interaction, National Institute for Laser Enhanced Science (NILES) Cairo University, Egypt. | ||
| 2Cancer Biology Department, National Cancer Institute (NCI), Cairo University, Cairo, Egypt. | ||
| 3Department of laser application in metrology, photochemistry and agriculture, National Institute for Laser Enhanced Science (NILES) Cairo University (CU), Egypt. | ||
| Abstract | ||
| Cancer is important cause of mortality, due to difficulty in finding safe, economical and specific effective therapeutic targets. The aim was to investigate the cytotoxicity of hybrid gold-chitosan nanospheres (Au@CsNs) on different cell lines using chitosan. Au@CsNs were analyzed by Zeta potential, UV-Visible spectroscopy, TEM and FTIR. Absorbance at 522 nm correlated to surface plasmon resonance (SPR) of AuNPs. TEM images show that Au@CsNs are spherical, with an average size of 12 ± 2 nm. Results of DPSS (diode pumped solid-state) laser irradiation show the photothermal laser stability of Au@CsNs. Au@CsNs showed anticancer effect using SRP assay on different cancer cell lines HCT, FADU, H460, and HEPG2. Our results suggest that Au@CsNs have an antiproliferative effect as there were a significant decrease in cell viability but this depends on the type of cancer cell line. In conclusion, Au@CsNs exhibited great anticancer activity subsequently it will be used in drug delivery and photothermal therapy in future work. | ||
| Keywords | ||
| Green Synthesis; Chitosan-coated Gold Nanoparticles; Cancer cells and Laser photostability | ||
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