L-Carnitine Essential Amino Acid: Beneficial Health Perspective | ||||
| Zagazig University Medical Journal | ||||
| Article 19, Volume 30, Issue 1.5, August 2024, Page 2137-2144 PDF (769.8 K) | ||||
| Document Type: Review Articles | ||||
| DOI: 10.21608/zumj.2023.252490.3029 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mai Said  1; Dalia Ibrahim Ahmed Mesallam 2; Elham Elshawadfy Abd-Elsamiee3; Eman Ahmed Alaa El-Din 4
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| 1Forensic medicine and clinical toxicology department. Faculty of medicine zagazig university. Egypt. | ||||
| 2Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||||
| 3Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Zagazig University, Egypt. | ||||
| 4Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Zagazig University. | ||||
| Abstract | ||||
| Background: L-carnitine is a quaternary ammonium compound. It and its two derivatives,(acetyl-L-carnitine and propionyl-L-carnitine), are considered essential amino acids. L-carnitine has been shown to improve physical performance in patients with certain diseases, including advanced cancer, fatigue, metabolic syndrome, and cardiovascular disease. L-carnitine is an important factor in the metabolism of long-chain fatty acids to produce energy. It exhibits a wide range of biological activities including anti-inflammatory, antiapoptotic, neuroprotective, and gastroprotective properties. L-carnitine prevents oxidative stress and regulates nitric oxide, cellular respiration, and the activity of enzymes included in defense against oxidative damage. Furthermore, these effects are attributed to its antioxidative and free radical scavenging activity. It also acts on cellular DNA and membranes, protecting them against destruction induced by free oxygen radicals. Aim: The current review provides the evaluation of l-carnitine, outlining its clinical applications as well as its mechanism of action. Conclusion: In summary, researchers have frequently emphasized the significance of l-carnitine administration as the cornerstone for protection against various diseases. | ||||
| Keywords | ||||
| Essential amino acid; L-Carnitine; Neuroprotective; Antioxidative; Antiapoptotic | ||||
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