Antimicrobial Efficacy of Nano Silver Fluoride, Fluoridated Self -Assembling Peptide and Sodium Fluoride Varnishes on Oral Streptococcus Mutans | ||
| Egyptian Dental Journal | ||
| Volume 70, Issue 1, January 2024, Pages 1-7 PDF (523.51 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/edj.2023.222067.2648 | ||
| Authors | ||
| Radwa Khalil Elkaddah* 1; Nasr Mohamed Attia2; Noha Elwassefy3; Abeer Mostafa Abdellatif4 | ||
| 1Pediatric Dentistry Departement ,Faculty of Dentistry,Mansoura University | ||
| 2Professor, Dental Public Health and Preventive Dentistry Department, Faculty of Dentistry, Mansoura University, Egypt. | ||
| 3Professor, Dental Biomaterials Department, Faculty of Dentistry, Mansoura University & Mansoura National University, Egypt | ||
| 4Professor, Pediatric Dentistry Department, Faculty of Dentistry, Mansoura University, Egypt | ||
| Abstract | ||
| ABSTRACT Aim: This study was designed to evaluate the antimicrobial efficacy of Nano Silver Fluoride, Fluoridated Self-assembling peptide, and Sodium Fluoride Varnishes on oral Streptococcus mutans bacteria. Materials and Methods: The Antimicrobial efficacy was evaluated using agar-disk diffusion method. Three Muller-Hinton agar plates cultured with Streptococcus mutans (ATCC1402) were prepared. Each plate received three remineralizing agents (Group 1: Nano Silver Fluoride, Group 2: Fluoridated Self-assembling peptide;and Group 3: Sodium Fluoride varnish; as a positive control group) on three filter paper discs. Then the plates were incubated anaerobically for 24 h at 37°C. The diameter of the formed inhibition zones was measured in millimeters by a ruler to assess the antimicrobial effect. Statistical analysis was done using Kruskal–Wallis test and Mann–Whitney post hoc Test. The level of significance was set at P ≤ 0.05. Results: Both Fluoridated Self-assembling peptide and Nano Silver Fluoride had antimicrobial effects against Streptococcus mutans. However, the median value of inhibition zone size (mm) was greater in Fluoridated Self-assembling peptide 21 (18-22) as compared to Nano Silver Fluoride 9 (8-9), with a statistically significant difference (P value = 0.046). Enamelast Sodium Fluoride varnish showed no inhibition zones. Conclusions: Fluoridated Self-assembling peptide had a better antimicrobial effect compared to Nano Silver Fluoride and conventional Sodium Fluoride varnish against Streptococcus mutans. | ||
| Keywords | ||
| Antimicrobial; Streptococcus Mutans; Nano Silver Fluoride; Fluoridated Self-assembling peptides | ||
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