COVID 19 associated coagulopathy | ||||
| Journal of Recent Advances in Medicine | ||||
| Volume 4, Issue 2, July 2023, Page 155-161 PDF (822.84 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jram.2023.233251.1223 | ||||
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| Authors | ||||
Dalia S. Eldawash  1; Sabah S. Oraby2; Samiha M. Abo-Bakr2; Dina A. Ibrahim3
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| 11Chest Diseases Department, Al-Ahrar Teaching Hospital, Zagazig, Egypt. | ||||
| 2Chest Diseases Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt. | ||||
| 3Clinical Pathology Diseases Department, Al-Ahrar Teaching Hospital, Zagazig, Egypt. | ||||
| Abstract | ||||
| Background: Critically ill COVID-19 patients are presented with coagulopathy and disseminated intravascular coagulation like massive clot formation. Consequently, coagulation tests are useful to distinguish severe cases of COVID-19. Objective: to assess the role of prothrombin time (PT), D‐dimer, platelet (PLT) count, and fibrinogen for detection of coagulopathy in patients with COVID-19 and to assess their relation to disease severity. Methodology: A cross sectional study was conducted on 80 patients with polymerase chain reaction (PCR) confirmed COVID-19 infection. The presenting symptoms, smoking, comorbidities, and high-resolution computed tomography of chest (HRCT) findings were reported. Measurements of the following laboratory parameters were done; complete blood count, liver and renal function tests, arterial blood gases, erythrocyte sedimentation rate, serum ferritin, C-reactive protein, PT, PTT, D-dimer and fibrinogen. Based on COVID severity criteria, they were classified into mild, moderate, severe, and critical cases. Results: Among the studied cases there were 33.75% have mild, 13.75% moderate, 38.75% severe and 13.75% critical COVID-19 infection. The dyspnea was significantly common in severe and critical groups (p< 0.001), while sore throat was significantly common in mild and moderate groups (p< 0.001). The ferritin was significantly higher in patients with either severe or critical COVID-19 than those with mild COVID-19, and in patients with severe COVID-19 than those with critical COVID-19. The severe and critical groups have significantly higher CORAD???-score compared to either mild or moderate groups. The white blood cells was significantly higher in the critical group than the mild group. The level of D-dimer and fibrinogen were significantly higher in the severe and critical groups compared to either the mild or moderate groups. The PT, PTT, D-dimer and fibrinogen have fair sensitivities and specificities for determination of COVID-19 severity, and for detection of critical COVID-19. Conclusion: Coagulation biomarkers increases in COVID-19 infected patients, and they increased further as the severity of the disease increased. | ||||
| Keywords | ||||
| SARS-COV2; D-dimer; fibrinogen; CAC; DIC | ||||
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