Association Between Bacterial Colonization and Stent Occlusion in Plastic Biliary Stents | ||||
| Benha Medical Journal | ||||
| Article 9, Volume 41, Issue 5, September 2024, Page 303-313 PDF (755.63 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2023.250015.1959 | ||||
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| Authors | ||||
Naglaa El-Toukhy Ramadan1; Muhammad Mostafa Abdel Gaffar2; Sarah Mohammad Atef3; Naglaa Fathy Abdelrhman4; Michael Safwat Moris  5; Tamer El-Eraky El-Azab6
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| 1Professor of Hepatology, Gastroenterology and Infectious Diseases, Faculty of Medicine, Benha University | ||||
| 2Consultant of Hepatology, Gastroenterology and Infectous diseases Presidant of General Organization of Teaching Hospitals and Institutes | ||||
| 3Fellow of Clinical Pathology, Ahmed Maher Teaching Hospital | ||||
| 4Fellow of microbiology Ahmad Maher Teaching Hospital | ||||
| 5(M.B.B.Ch, October 6 University) | ||||
| 6Assistant Professor of Hepatology, Gastroenterology and Infectious Diseases, Faculty of Medicine, Benha University | ||||
| Abstract | ||||
| Background: Biliary stent occlusion is a significant clinical concern with potentially severe consequences for patients. This study aimed to evaluate common microorganisms detected by culture from plastic biliary stents, assess their association with stent occlusion, and evaluate their antimicrobial sensitivity. Methods: Forty patients with plastic biliary stents were included in this study. They were divided into two groups: Group (I) 20 patients with clinical signs of stent occlusion and Group (II) 20 patients scheduled for stent extraction within three months after placement. Various clinical, laboratory, and imaging assessments were conducted. The plastic stents were extracted and subjected to microbiological culture to identify aerobic and anaerobic organisms, followed by antimicrobial sensitivity testing. Results: Patients in Group (I) exhibited a higher prevalence of clinical symptoms indicative of stent occlusion, abnormal vital signs, and elevated laboratory parameters (TLC, ESR, CRP, Total Bilirubin., Direct Bilirubin, ALP, ALT, AST, PT, INR and creatinine) compared to Group (II). Microbiological analysis revealed the presence of various organisms, with Klebsiella sp, Proteus, Pseudomonas, and E. coli being the most common. Sensitivity and resistance to antibiotics varied among these microorganisms. Conclusion: Klebsiella was prevalent in stent occlusion (65%), while Proteus dominated non-occlusion (60%). No anaerobic organisms were found. Amikacin, Meropenem, and Imipenem showed the highest sensitivity of microbes in patient with stent occlusion, and Meropenem, Colistin, and Imipenem the highest sensitivity of microbes in patient with non- stent occlusion. Both groups exhibited 100% resistance to various antibiotics. | ||||
| Keywords | ||||
| Biliary Stents; Stent Occlusion; Bacterial Colonization; Antimicrobial Sensitivity; Microbiological Assessment | ||||
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