Evaluation of the efficacy of camel milk lactoferrin nanoliposome against colorectal cancer | ||
| Journal of Plant and Food Sciences | ||
| Article 5, Volume 1, Issue 2, December 2023, Pages 45-57 PDF (664.2 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jpfs.2024.259780.1005 | ||
| Authors | ||
| Sameh Abdallah Hendy* 1; A. H. Gamal El Din2; Ezzat Ahmed Abdel Fatah2; Wafaa M. Salama3; Hosam El-Din Mostafa4; Rania M. Azab4; Sameh S. Yacoub5 | ||
| 1Dairy Science Department, Faculty of Agriculture, Al-Azhar University, Cairo, Egypt.gypt | ||
| 2Dairy Science Department, Faculty of Agriculture, Al-Azhar University, Cairo, Egypt. | ||
| 3Dairy Res. Dept., Food Technology Research Institute, Agriculture Research Center, Giza, Egypt. | ||
| 4National Institute of Laser Enhanced Sciences (NILES). Cairo University, Giza, Egypt. | ||
| 5Faculty of Agriculture, Damanhour University, Damanhour, Egypt. | ||
| Abstract | ||
| Colorectal cancer (CRC) is a significant cause of death and cancer-related mortality worldwide. Lactoferrin (LF) is a promising molecule that was found to inhibit the growth of cancerous tumor. This study explores the effect of camel milk lactoferrin nanoliposome (LFnl) on colorectal cancer (HTC-116 cells) as a potential therapeutic agent against colorectal cancer. The total purified camel milk LF concentration was 200 mg/l. Film hydration technique was used to produce LFnl. Advanced characterization revealed distinct nanoliposome shapes with a clear two-layered structure. The particle size ranged between 28.3 – 139 nm, and the zeta potential value was -22.6 mV. Exceptional encapsulation efficiency of 99.32% was achieved. The examination of HTC-116 cells and normal cells WI-38 elucidated an IC50 value of 40.5±0.9 µg/ml. while, the cytotoxicity assessments conducted on WI-38 cells exhibited a CC50 value of 43.5±0.3 µg/ml. This result indicated that LFnl should be used carefully when treated colorectal cancer. | ||
| Keywords | ||
| Camel Milk; Lactoferrin; Nanoliposome; Colorectal Cancer | ||
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