LncRNA HOTAIR as a novel biomarker in Psoriasis | ||
| Fayoum University Medical Journal | ||
| Volume 12, Issue 3, December 2023, Pages 53-62 PDF (436.76 K) | ||
| Document Type: Full Length research Papers | ||
| DOI: 10.21608/fumj.2023.336853 | ||
| Authors | ||
| Rana Raafat Mohammed Saad* 1; Amr Zahra2; Azza Elamir2; Basma Mohammed3; Hassan Elsayed2 | ||
| 1Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt | ||
| 2Medical Biochemistry and Molecular Biology | ||
| 3Dermatology, STDs and Andrology | ||
| Abstract | ||
| Introduction: Psoriasis is an inflammatory skin disease. Immunological, genetic, and environmental factors have all been implicated in the development of psoriasis. (HOTAIR) is a lncRNA that regulates gene expression through epigenetic modulation and post-translational gene regulation. Aim of the study: To compare the expression of HOTAIR in psoriasis patients with that of normal, healthy subjects. Subjects and Methods: A case-control study was conducted on 40 psoriatic patients who were recruited from a dermatology outpatient clinic and 20 age- and sex-matched healthy control subjects. Serum samples were collected, and lncRNA HOTAIR expression was detected by quantitative real-time polymerase chain reaction (qRT-PCR). Results: Our results demonstrated a statistically significant up-regulation of the HOTAIR gene expression in the serum of psoriasis patients in comparison with the control subjects (P < 0.001). Conclusion: This elevated level of Lnc-HOTAIR in the serum of psoriasis patients suggests its possible contribution to the pathogenesis of the disease. | ||
| Keywords | ||
| Psoriasis; LncRNA; HOTAIR; qRT-PCR | ||
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