Assessment of Micro RNAs 31 In Pathogenesis of Hypertrophic Scar | ||
| Fayoum University Medical Journal | ||
| Volume 12, Issue 3, December 2023, Pages 72-78 PDF (290.99 K) | ||
| Document Type: Full Length research Papers | ||
| DOI: 10.21608/fumj.2023.336859 | ||
| Authors | ||
| Talal Abdel-Rahem1; Olfat Shaker2; Mohamed Hassan Mohamed* 3; Sara Hesham Rezk* 4 | ||
| 1Dermatology & STD and Andrology department, Fayoum University | ||
| 2Biochemistry department, Cairo University | ||
| 3Dermatology, STDs and Andrology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt. | ||
| 4Dermatology department, Faculty of Medicine, Fayoum University, Fayoum, Egypt | ||
| Abstract | ||
| Introduction: A hypertrophic scar (HS) is a pathological result of wound healing. It is caused by the excessive accumulation of extracellular matrix components. MicroRNAs regulate protein-coding gene expression, participating in different biological processes. MiR-31 has a wide range of molecular targets and is specifically expressed in various tissues and organs. Aim of the study: to evaluate the role of miR-31 in hypertrophic scar parthenogenesis. Subjects and Methods: The study included 20 hypertrophic scar patients and 20 healthy subjects as a control. The level of the microRNAs in serum was estimated using serum isolation Then, cDNA was formed using the RT Kit. PCR will be conducted by real-time PCR for the amplification of the genes. Results: There was a highly statistically significant difference between the two groups of miR-31. The level of mir-31 was much higher in the patient group than in the normal control. Conclusion: Our findings suggest that miR-31 is pro-fibrotic and that its up-regulation stimulates fibrosis. This may provide a new direction for the study of the parthenogenesis of hypertrophic scars. | ||
| Keywords | ||
| Hypertrophic scar; MicroRNA; MiR-31 | ||
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