Synergistic Activity of Cisplatin and Anise Extract Nanoparticles to Inhibit the Tumor of Mammary Cancer Cells in Mice | ||||
| Egyptian Journal of Histology | ||||
| Article 11, Volume 48, Issue 1, March 2025, Page 174-185 PDF (642.78 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejh.2024.242091.1963 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Nael Mohammed Sarheed 1; Hamid K AL-tameemi  2; Ameer Ali Imarah3
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| 1College of Medicine, Al-Muthanna University, Al-Muthanna-Iraq. | ||||
| 2Diyala University, Faculty of science,Biology department. | ||||
| 3Biology Department-Faculty of Science -kufa University | ||||
| Abstract | ||||
| Cancer is a major health problem worldwide and is one of the leading causes of death. Preventing tumor development is a significant challenge due to the similarity in cellular mechanisms between cancerous and normal cells; however, biological substances have high efficiency against cancerous cells and low toxicity against normal cells associated with a good prognosis. Therefore, the current study is designed to study the role of Anise extract (A.E.) and Anise extract- Chitosan nanoparticles in the synergistic effect with Cisplatin in the treatment of tumor-induced in female mice. Materials and methods: Five groups of female mice, six mice for each group, were included to achieve the goal of the present study. These study groups were control, tumor-induced, Cisplatin treated, Cisplatin – Anise extract treated, and Cisplatin- Anise extract- Chitosan nanoparticles treated groups. The tumor size and some biomarkers (IL-33, LRG-1, and CRP) were considered indicators for tumor development and response to the treatment protocol. Results: The present study found that the tumor size in the tumor-induced group reached 33.1 mm after 30 days of inducement, while the tumor size in the treated group was significantly smaller than in the tumor-induced group. The tumor size in the Cisplatin- Anise extract group was smaller than the Cisplatin treated group. Also, the effect of Cisplatin against a tumor increased when combining anise extract with Chitosan nanoparticles. The biomarkers showed that IL-33, LRG-1, and CRP levels were higher in the tumor group than in the control and other study groups. Conclusion: The current study concluded that the anise extract has high effectiveness in reinforcing Cisplatin action against tumor development and, simultaneously, increased their effect by nanoparticles. | ||||
| Keywords | ||||
| Anise extract; biomarkers; cispaltin; nanoparticles; tumor | ||||
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