SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME HITHERTO UNKNOWN 4-OXO-THIAZOLES AND THIAZOLO [3, 2-A] PYRIDINES | ||
| Al-Azhar Bulletin of Science | ||
| Article 8, Volume 2018, Issue 12, December 2018, Pages 91-104 PDF (664.46 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/absb.2018.33772 | ||
| Authors | ||
| Gameel El-hag ali; Said A. Shedid* ; Gameel A. El-hag ali | ||
| Department of Chemistry, Faculty of Science, Alazhar University, Cairo, Egypt | ||
| Abstract | ||
| 2-(4-Oxothiazolidin-2-ylidene) acetonitrile and ethyl -2-(4-oxothiazolidin-2-ylidene) acetate (1a, b), were condensed with anthralaldehyde (1:1 molar ratio) and gave 4, 5-dihydro-4-oxothiazole derivatives (2a, b). Refluxing of 2-(Antharacene-9-yl-methylene) malononitrile in acetic acid with thioglycollic acid gave (3). 4-Thiazolidinones containing bis aryl methylidine moieties (4a-c) and (5a, b) were produced via condensation of either (2a) or (3) with different aromatic aldehydes (1:1 molar ratio). Heating of (2a) with α-substituted cin- namonitriles gave the expected substituted thiazolo [3, 2-a] pyridines (6a-d), (8) and (10a-c). The synthesized compounds have been screened for their antimicrobial activities against some selected species of Gram-positive (G+). Gram-negative (G-) bacteria and 3 different types of fungi. They were found to be more active against Gram positive than Gram negative bacteria. | ||
| Keywords | ||
| Thiazolidinones; Thizolopyridines; Antibacterial; Antifungal; Synthesis | ||
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