Value of serum Copeptin in Early Diagnosis and prediction of short-term outcomes in Acute coronary syndrome patients
Khalil, W., Dwedar, A., abozeid, A., Mansour, K. (2024). Value of serum Copeptin in Early Diagnosis and prediction of short-term outcomes in Acute coronary syndrome patients. EKB Journal Management System, 30(1.7), 3728-3742. doi: 10.21608/zumj.2024.263145.3117
Wael Ali Khalil; Ashraf Dwedar; ahmed lotfy abozeid; Kamal saad Mansour. "Value of serum Copeptin in Early Diagnosis and prediction of short-term outcomes in Acute coronary syndrome patients". EKB Journal Management System, 30, 1.7, 2024, 3728-3742. doi: 10.21608/zumj.2024.263145.3117
Khalil, W., Dwedar, A., abozeid, A., Mansour, K. (2024). 'Value of serum Copeptin in Early Diagnosis and prediction of short-term outcomes in Acute coronary syndrome patients', EKB Journal Management System, 30(1.7), pp. 3728-3742. doi: 10.21608/zumj.2024.263145.3117
Khalil, W., Dwedar, A., abozeid, A., Mansour, K. Value of serum Copeptin in Early Diagnosis and prediction of short-term outcomes in Acute coronary syndrome patients. EKB Journal Management System, 2024; 30(1.7): 3728-3742. doi: 10.21608/zumj.2024.263145.3117

Value of serum Copeptin in Early Diagnosis and prediction of short-term outcomes in Acute coronary syndrome patients

Zagazig University Medical Journal
Article 5, Volume 30, Issue 1.7, October 2024, Page 3728-3742  XML PDF (1012.25 K)
Document Type: Original Article
DOI: 10.21608/zumj.2024.263145.3117
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Authors
Wael Ali Khalil email 1; Ashraf Dwedar2; ahmed lotfy abozeid3; Kamal saad Mansour4
1Department of Cardiology zagazig university
2cardiology department, faculty of medicine, Zagazig university, egypt
3cardiology department, faculty of medicine, Zagazig university, Egypt
4Department of Cardiology, faculty of medicine, zagazig university, Egypt
Abstract
The introduction: The early diagnosis and exclusion of acute coronary syndrome is still challenging, that requires monitoring of the patients and serial measurements of cardiac biomarker Hs-c-TnsI . The addition of cardiac biomarker serum Copeptin may reflect the early ischemic cardiac injury. We aimed at detection of the diagnostic value of serum copeptin level and its role in prediction of short-term outcomes; MACCE in STEMI patients as a new cardiac biomarker. Subjects and methods: We included ninety patients attended an emergency cardiac care department due to acute chest pain (within less than three hours from onset of the chest pain) and were divided into; the 1st group included forty patients (acute STEMI who successfully received primary PCI). The 2nd group included fifty Patients (other diagnosis; (non-AMI)). The study endpoint was MACCE. The patients were subjected to the full laboratory profile (CBC, kidney function tests, total CK, CK- MB, highly sensitive Cardiac Troponin I, serum Copeptin). Results: The ROC analysis showed that At AUC of 0.891 and cut off value of >12.4 pmol/l, copeptin had a sensitivity of 75 % ,specificity 92 %, PPV 88.2 % ,NPV 82.1 % and accuracy 84.4 % in early diagnosis of acute MI. There was statistical significance of serum Copeptin level that correlated with CK-MB and hs-cTnI. In conclusion, our study revealed that Copeptin can early diagnose acute myocardial infarction but not superior to highly sensitive troponin. Higher serum copeptin levels were independent prognostic predictors of MACCE in acute STEMI patients during short-term follow up
Keywords
Copeptin; STEMI; MACCE
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