The Role of Sputum Clusterin in Childhood Asthma in Zagazig University Hospitals: A case control Study. | ||||
| Zagazig University Medical Journal | ||||
| Article 32, Volume 30, Issue 8.1, November 2024, Page 4079-4090 PDF (903.11 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2024.261252.3101 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Eman Tantawy  1; Dina mohamed shokry2; Rabab Elbehedy3; Reham Mohamed El Shabrawy4; Maha Abdelaziz El sayed Noah5
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| 1Paediatric Department, Faculty of Medicine, Zagazig University, Egypt | ||||
| 2pediatrc,medicine,zagazig | ||||
| 3pediatric | ||||
| 4Medical Microbiology and Immunology,Faculty of medicine, Zagazig | ||||
| 5Pediatrics Department, Faculty of Medicine, Zagazig University, Egypt | ||||
| Abstract | ||||
| Abstract: Clusterin serves as a highly sensitive cellular detector for oxidative stress and has been extensively investigated as a significant indicator for disorders related with inflammation. The evaluation of clusterin in pediatric population diagnosed with has not been fully evaluated. Methods: This is a case-control study. It was a prospective study carried on Pulmonology unit Pediatric department, Zagazig University hospitals including 54 Patients 7 – 14 years in age, both genders were included, this study was planned to include fifty four (54) subjects; thirty six (36) asthmatic children as patients and another eighteen (18) healthy children as controls. Results: In the current research we had reported that there was astatistically significant disparities between studied groups regarding sputum clusterin (p value of ≤0.001) as children diagnosed with stable asthma had elevated levels of clusterin compared to the healthy control group [14.82(13.74–16.59) ng/mL vs 11.75 (10.82-12.54) ng/mL]. During asthma exacerbation, the levels of clusterin in sputum were decreased compared to stable asthma [8.13 (4.31–9.41) ng/mL vs 14.82 (13.74–16.59) ng/mL]. Our investigation reported a statistically significant association between the severity of asthma and serum Clusterin in severe asthma as patients with severe asthma had elevated levels of clusterin in comparison to those who had mild asthma [16.47 (15.76–18.12) ng/mL vs 13.79 (12.85-14.03) ng/mL]. Conclusion: Clusterin levels detected in sputum can be considered as a biomarker of airways inflammation and the intensity of symptoms, making it a valuable tool for evaluating and treating childhood asthma. | ||||
| Keywords | ||||
| Clusterin; Asthma; Childhood; Pediatric; Severity.&lrm | ||||
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