The Impact of The Non-Polar Extract from Cyperus Rotundus Tubers on The Rats' Hepatotoxicity Induced by Alpha-Cypermethrin

Al-Al-kashef, Amr S.; Gaafar, Alaa A.; Ibrahim, Eman A.; Nooman, Mohamed U.; El- Bana, Mona A.; Hussein, Jihan

doi:10.21608/ejchem.2024.258938.9104

	The Impact of The Non-Polar Extract from Cyperus Rotundus Tubers on The Rats' Hepatotoxicity Induced by Alpha-Cypermethrin
Egyptian Journal of Chemistry
Volume 67, Issue 13, December 2024, Pages 599-607 PDF (447.91 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2024.258938.9104
Authors
Amr S. Al-Al-kashef¹; Alaa A. Gaafar²; Eman A. Ibrahim²; Mohamed U. Nooman¹; Mona A. El- Bana³; Jihan Hussein^* ³
¹Biochemistry Department, National Research Centre, Dokki, P.O,Giza 12622, Egypt.
²Plant Biochemistry Department, National Research Centre, Dokki,P.O, Giza 12622, Egypt.
³Medical Biochemistry Department, National Research Centre, Dokki, Giza, P.O. 12622 Egypt,
Abstract
Background: One of the most widely used insecticides, is alpha-cypermethrin (α-CYP). Excessive dependence on such insecticides leads to severe environmental pollution, negatively affecting human and animal health. Aim: The goal of the current investigation based on utilizing Cyperus rotundus tuber non-polar extract, to assist reducing the deleterious impact of α-CYP on liver tissues of male albino rats. Results: FT-IR analysis identified the most important active compounds present in the extract. While the active biochemical ones were confirmed by individualization and identification utilizing GC/MS. The results indicated that the most important active compounds in the hexane extract were oxygenated compounds,17-octadecynoic acid (60.51%) and 9-octadecenoic acid, methyl ester (6.54%) in addition to nitrogenated compounds, such as histidyl histidine (4.75 %). The results showed that the C. rotundus extract administration decreased liver enzymes; alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Also, it increased antioxidant; glutathione (GSH), superoxide dismutase (SOD) enzyme, decreased oxidant; malondialdehyde (MDA), and nitric oxide (NO). Furthermore, it decreased liver inflammatory markers; nuclear factor-κB (NF-κB), adiponectin, and lipocalin. Conclusion: Results indicated that C. rotundus hexane extract exerts a potent protective effect against α-CYP-induced oxidative damage and inflammation in rats’ liver tissues.
Keywords
Alpha-cypermethrin; Cyperus rotundus; Antioxidants; Fibrosis; Inflammation; Oxidative stress

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