Silica sulfuric acid / ethylene glycol: An Efficient Eco-friendly Catalyst for One-pot Synthesis of Tricyclic and Tetarcyclic Dihydropyrimidine Derivatives.

Abdelazeem, Nagwa; Basyouni, Wahid; Abbas, Samir; El-Bayouki, Khairy; El-kady, Mohamed

doi:10.21608/ejchem.2019.13142.1827

	Silica sulfuric acid / ethylene glycol: An Efficient Eco-friendly Catalyst for One-pot Synthesis of Tricyclic and Tetarcyclic Dihydropyrimidine Derivatives.
Egyptian Journal of Chemistry
Article 8, Volume 62, Issue 12, December 2019, Page 2265-2276 PDF (1.26 MB)
Document Type: Review Articles
DOI: 10.21608/ejchem.2019.13142.1827
View on SCiNiTO
Authors
Nagwa Abdelazeem ¹; Wahid Basyouni ¹; Samir Abbas¹; Khairy El-Bayouki¹; Mohamed El-kady²
¹Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt.
²Chemistry Department, Faculty of Science, Ain Shams University
Abstract
A simple and efficient eco-friendly chemical procedures were developed for the synthesis of series of tricyclic and tetarcyclic dihydropyrimidine derivatives in excellent yields via a one-pot, multi-component reaction in the presence of silica sulfuric acid / ethylene glycol catalyst. The Tricyclic dihydropyrimidine derivatives 1a-g (benzo[4,5]imidazo[1,2-a]pyrimidine derivatives) were synthesized in high yields and high purity with short reaction times by reacting 2-aminobenzimidazole, aldehydes and ethyl acetoacetate. Also, the tetracyclic dihydropyrimidine derivatives 3a-f (benzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidin-4(1H)-one derivatives) were synthesized by the reaction of 2-aminobenzimidazole, aldehydes and cyanoacetamide. This present new protocol offers shorter reaction time, high yields and low cost. This method provides much improved protocol over the existing methods.
Keywords
Silica sulfuric acid/ethylene glycol; Dihydropyrimidine derivatives Benzo[4,5]imidazo[1,2-a]pyrimidine; 2-Aminobenzimidazole


Statistics Article View: 913 PDF Download: 632