Toxic Effects of Carbendazim on Brain of Male albino Rats with Possible Protective Role of Linalool | ||
| Zagazig University Medical Journal | ||
| Article 40, Volume 30, Issue 8.1, November 2024, Pages 4158-4171 PDF (1.3 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2024.266383.3146 | ||
| Authors | ||
| Eman El-Sayed Khayal1; Eman Fawzi Aboualkhair* 1; Zakaria. A. Elzawahry1; Khaled Hamed Elmosalamy2; Mohammad Zayed Mohammad Hassan1 | ||
| 1Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Zagazig University | ||
| 2Histology and Cell Biology department, Faculty if medicine, Zagazig University | ||
| Abstract | ||
| Background: The growing concern for environment is usage of hazardous pesticides increasingly frequently. One systemic fungicide that is regarded as a persistent environmental pollutant is carbendazim (CBZ). Pharmacological activity of linalool has been shown to exhibit a range of characteristics, including antibacterial, anti-inflammatory, antioxidant, anticancer effects. Objectives: The current study designed for estimation of protective mechanism of linalool in CBZ-induced brain damage in rats. Subjects and methods: This experimental study consisted of negative control, positive control, linalool (50 mg/kg), CBZ (500 mg/kg), combined CBZ linalool groups for 8 consecutive weeks. 35 rats were randomly allocated into G (I): Negative control group regular diet tap water. G (II): Positive control group: 1 ml corn oil (as a vehicle) once daily by oral gavage for 8 weeks. G (III): Linalool-treated group: linalool 50 mg/kg B.W. according to once daily by oral gavage for 8 weeks. G (IV): Carbendazim-treated group: 500 mg/kg B.W. of carbendazim (1/10 LD50) dissolved in 1ml corn oil once daily by oral gavage for 8 weeks (Oral LD50 of carbendazim in rats equal 5000 mg/kg). G (V): Carbendazim and linalool-treated group linalool 50 mg/kg then after 1 hour received carbendazim 500 mg/kg once daily by oral gavage for 8 weeks. Results: Linalool co-treatment significantly improved CBZ-induced disturbance in brain level of acetylcholinesterase when compared to CBZ group. Also, linalool alleviated CBZ induced a decrease in SOD levels and an rise in levels of MDA in brain tissues. Conclusion: linalool-mediated brain protection in CBZ-treated rats possessed antioxidant and anti-inflammatory effects. | ||
| Keywords | ||
| carbendazim; fungicide; linalool; brain; acetylcholinesterase | ||
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