Relation Between Levels of Fibroblast Growth Factor 23 and the Risk of Ischemic Stroke
Osama, A., Saad, A., Elshamly, S., Abd El Razek, R., Salem, M. (2023). Relation Between Levels of Fibroblast Growth Factor 23 and the Risk of Ischemic Stroke. EKB Journal Management System, 26(10), 1-5. doi: 10.21608/scumj.2023.342538
Ahmed Osama; Alaa Saad; Samir Elshamly; Reda Abd El Razek; Mohamed Salem. "Relation Between Levels of Fibroblast Growth Factor 23 and the Risk of Ischemic Stroke". EKB Journal Management System, 26, 10, 2023, 1-5. doi: 10.21608/scumj.2023.342538
Osama, A., Saad, A., Elshamly, S., Abd El Razek, R., Salem, M. (2023). 'Relation Between Levels of Fibroblast Growth Factor 23 and the Risk of Ischemic Stroke', EKB Journal Management System, 26(10), pp. 1-5. doi: 10.21608/scumj.2023.342538
Osama, A., Saad, A., Elshamly, S., Abd El Razek, R., Salem, M. Relation Between Levels of Fibroblast Growth Factor 23 and the Risk of Ischemic Stroke. EKB Journal Management System, 2023; 26(10): 1-5. doi: 10.21608/scumj.2023.342538

Relation Between Levels of Fibroblast Growth Factor 23 and the Risk of Ischemic Stroke

Suez Canal University Medical Journal
Article 1, Volume 26, Issue 10, October 2023, Pages 1-5    PDF (235.98 K)
Document Type: Original Article
DOI: 10.21608/scumj.2023.342538
Authors
Ahmed Osama1; Alaa Saad2; Samir Elshamly* 1; Reda Abd El Razek1; Mohamed Salem1
1Department of Neurology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
2Department Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
Abstract
Background: Fibroblast growth factor 23 (FGF23) is a hormone secreted by osteocytes that regulates homeostasis of phosphates by inducing phosphaturia and inhibiting the development of calcitriol. Elevated FGF23 is linked with cardiovascular events and mortality. The role of FGF23 as a risk factor for ischemic stroke is unclear. Aim: The study aimed to evaluate the levels of FGF23 and risk of ischemic stroke. Subjects and Methods: This case-control study included 44 adult ischemic stroke patients and 44 healthy controls. The levels of FGF23 were estimated using Enzyme-Linked Immune Sorbent Assay (ELISA) method. Results: FGF23 levels were significantly higher in ischemic stroke patients compared to the control group. Receiver operating characteristics (ROC) curve analysis showed high sensitivity (84.1%) and specificity (95.5%) in detecting ischemic stroke. Analysis of variance (ANOVA) test displayed a statistically significant relation between levels of FGF23 and the severity of stroke according to National Institutes of Health Stroke Scale (NIHSS). There were no significant relations between FGF23 levels and carotid artery stenosis or the lesion location on magnetic resonance imaging (MRI) according to oxford classification of stroke. Conclusion: FGF23 levels were significantly higher among ischemic stroke patients.
 
Keywords
Cerebrovascular events; sensitivity; specificity; carotid artery stenosis
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