A study of the association between plasma interleukin-21 gene polymorphism and the susceptibility to rheumatoid arthritis in Egyptian patients

Abdelsamea, Soheir Abdelrahman; Khashaba, Rana Atef; Amer, Arwa S.; Abd Allah Ahmed khalifa, Omnia Abd elmonsef; Ameen, Seham Gouda

doi:10.21608/bmfj.2024.265553.2004

	A study of the association between plasma interleukin-21 gene polymorphism and the susceptibility to rheumatoid arthritis in Egyptian patients
Benha Medical Journal
Article 10, Volume 41, Issue 1, March and April 2024, Pages 94-100 PDF (501.76 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2024.265553.2004
Authors
Soheir Abdelrahman Abdelsamea¹; Rana Atef Khashaba²; Arwa S. Amer³; Omnia Abd elmonsef Abd Allah Ahmed khalifa^* ⁴; Seham Gouda Ameen⁵
¹Department of Clinical and Chemical Pathology, Faculty of medicine, Benha University
²Department of Clinical and Chemical Pathology, Faculty of medicine, Banha University.
³Department of Rheumatology, Rehabilitation and Physical Medicine, Faculty of medicine, Benha University
⁴M.B.B.CH Clinical and Chemical Pathology, Faculty of medicine, Benha University
⁵Department of clinical pathology-Faculty of medicine-Benha University
Abstract
Background: Rheumatoid arthritis (RA) is a prevalent autoimmune disease characterized by joint destruction, chronic inflammation, and autoantibody production. IL-21 plays an essential role in the immunopathology of RA. The aim of the study: was to investigate the association between plasma interleukin-21 gene polymorphism and the susceptibility to rheumatoid arthritis in Egyptian patients and to find out its relation to disease activity. Methods: This case control study was conducted on 100 subjects; divided into two groups:Group(I):70 RA patients,Group(II):30 apparently healthy matched subjects.Through history taking, clinical examination and assessment of IL-21 gene rs2055979 by quantitative Real Time PCR (qRT-PCR).Disease activity was evaluated using DAS-28 score. Results: RA patients were significantly associated with higher frequency of rs2055979 AA genotype and A allele (p= 0.023, 0.028 respectively) with risk to develop RA.IL-21 genotypes AA and CA were significantly associated with higher DAS-28 when compared to CC genotype (p≤0.05). Conclusion: Our results showed that genetic alterations in the IL-21 gene are associated with susceptibility to rheumatoid arthritis in the Egyptian population.
Keywords
Rheumatoid arthritis; IL-21 gene; autoimmune disease; polymorphisms

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