Effect of Sacubitril/Valsartan on heart rate turbulence in patients with heart failure with reduced ejection fraction

Abdelaziz, Asmaa Ahmed; Taha, Nasser Mohammed; Abdelrhman, tarek Mohamed; Setohi Abdelhafez, Amr Mostafa

doi:10.21608/mjmr.2024.268297.1661

	Effect of Sacubitril/Valsartan on heart rate turbulence in patients with heart failure with reduced ejection fraction
Minia Journal of Medical Research
Articles in Press, Accepted Manuscript, Available Online from 26 February 2024
Document Type: Original Article
DOI: 10.21608/mjmr.2024.268297.1661
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Authors
Asmaa Ahmed Abdelaziz ¹; Nasser Mohammed Taha²; tarek Mohamed Abdelrhman³; Amr Mostafa Setohi Abdelhafez⁴
¹Department of cardiology, faculty of medicine, Minia university, Minia, Egypt
²cardiology department,Minia university, Egypt
³cardiology department,faculty of medicine ,Minia university
⁴cardiology department ,faculty of medicine ,minia university
Abstract
Abstract Background: HRT is noninvasive tool that predicts sudden cardiac death and arrhythmic events in patients with heart failure with reduced ejection fraction Aim: the current study aimed to know the effect of sacubitril / valsartan drug (Entresto) on the (HRT) in the patients with heart failure with reduced ejection fraction (EF ≤ 35 %). Methods: We included 42 patients with heart failure with reduced ejection fraction (EF ≤35 %). Patients with normal sinus rhythm and at least 5 PVCs fulfilling the criteria for measurement of HRT in Holter. A comparative study was done between HRT parameters before and 3 months after sacubitril / valsartan treatment. Results: We found that HRV index, mean HR, Maximum HR and total number of beats in 24 hrs. were improved after 3 months of sacubitril/ valsartan treatment HRT score did not improve but it predicted development of complications . Conclusion: Although HRT score did not improve after 3 months of sacubitril/ valsartan, HRT could predict development of complications such as sudden death , VT , Runs of salvos and PVCs more than 10% .
Keywords
Sacubitril/ valsartan; Heart rate turbulence; sudden cardiac death; heart failure


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