Effect of Sacubitril/Valsartan on heart rate turbulence in patients with heart failure with reduced ejection fraction | ||
| Minia Journal of Medical Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 26 February 2024 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2024.268297.1661 | ||
| Authors | ||
| Asmaa Ahmed Abdelaziz* 1; Nasser Mohammed Taha2; tarek Mohamed Abdelrhman3; Amr Mostafa Setohi Abdelhafez4 | ||
| 1Department of cardiology, faculty of medicine, Minia university, Minia, Egypt | ||
| 2cardiology department,Minia university, Egypt | ||
| 3cardiology department,faculty of medicine ,Minia university | ||
| 4cardiology department ,faculty of medicine ,minia university | ||
| Abstract | ||
| Abstract Background: HRT is noninvasive tool that predicts sudden cardiac death and arrhythmic events in patients with heart failure with reduced ejection fraction Aim: the current study aimed to know the effect of sacubitril / valsartan drug (Entresto) on the (HRT) in the patients with heart failure with reduced ejection fraction (EF ≤ 35 %). Methods: We included 42 patients with heart failure with reduced ejection fraction (EF ≤35 %). Patients with normal sinus rhythm and at least 5 PVCs fulfilling the criteria for measurement of HRT in Holter. A comparative study was done between HRT parameters before and 3 months after sacubitril / valsartan treatment. Results: We found that HRV index, mean HR, Maximum HR and total number of beats in 24 hrs. were improved after 3 months of sacubitril/ valsartan treatment HRT score did not improve but it predicted development of complications . Conclusion: Although HRT score did not improve after 3 months of sacubitril/ valsartan, HRT could predict development of complications such as sudden death , VT , Runs of salvos and PVCs more than 10% . | ||
| Keywords | ||
| Sacubitril/ valsartan; Heart rate turbulence; sudden cardiac death; heart failure | ||
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