Histological study of effect of cadmium toxicity on ovarian tissue
Abdel-Aziz Helmya, D., Embabyb, A., El-saeed, A. (2023). Histological study of effect of cadmium toxicity on ovarian tissue. EKB Journal Management System, 1(2), 33-43. doi: 10.21608/ejctr.2023.194004.1001
Dalia Hussien Abdel-Aziz Helmya; Azza Saleh Embabyb; Amany Mohammed El-saeed. "Histological study of effect of cadmium toxicity on ovarian tissue". EKB Journal Management System, 1, 2, 2023, 33-43. doi: 10.21608/ejctr.2023.194004.1001
Abdel-Aziz Helmya, D., Embabyb, A., El-saeed, A. (2023). 'Histological study of effect of cadmium toxicity on ovarian tissue', EKB Journal Management System, 1(2), pp. 33-43. doi: 10.21608/ejctr.2023.194004.1001
Abdel-Aziz Helmya, D., Embabyb, A., El-saeed, A. Histological study of effect of cadmium toxicity on ovarian tissue. EKB Journal Management System, 2023; 1(2): 33-43. doi: 10.21608/ejctr.2023.194004.1001

Histological study of effect of cadmium toxicity on ovarian tissue

Egyptian Journal of Cell and Tissue Research
Volume 1, Issue 2, April 2023, Page 33-43  XML PDF (1.15 MB)
Document Type: Original articles
DOI: 10.21608/ejctr.2023.194004.1001
View on SCiNiTO View on SCiNiTO
Authors
Dalia Hussien Abdel-Aziz Helmya; Azza Saleh Embabyb email ; Amany Mohammed El-saeed
Histology department, Faculty of Medicine, Beni-Suef University, Egypt
Abstract
Cadmium is a widespread and dangerous material that leads to different harmful cellular changes up to death. The goal of this study is to detect cadmium damaging effect on ovaries of adult female albino rat . A total of 14 adult female albino rats were divided into two groups, each group was consisted of 7 rats . The control group ( group I) was given only saline orally and the cadmium-treated group (group II) was given CdCl2 dissolved in saline at a dose of 5 mg/kg  for 28days. The animals of two groups were sacrificed at the same time and their right ovaries were rapidly dissected out. The specimens of each group were processed for light microscopic examination. They were stained with hematoxylin and eosin and masson's trichrome stains for evaluating histopathological changes in ovarian  structure. Quantitative morphometric, and statistical studies were performed. Histological changes in cadmium- treated group were in the form of irregular outline of the ovary with flat squamous germinal epithelium , massive loss of follicles and many atretic follicles with markedly dilated and congested cortical blood vessels. Masson's trichrome stained sections showed marked deposition of collagen fiber in the cortical stroma.
Keywords
ovary; histology; damage
References
 

  1. Ross MH and Pawlina W .Female reproductive system in: A histology text and atlas with cell and molecular biology. 7th ed. Lippincott, williams and wilkins, USA. P: ;2016; 834-848.
  2. Young B, O’Dowd G and Woodford Ph .Female reproductive system In: Wheater's Functional Histology. A Text and Coloured Atlas. Sixth ed. Churchill Livingstone Elsevier. USA; 2014 ; 351-359.
  3. Sinisa Djurasevic, Adel Jama, Nebojsa Jasnic .The Protective Effects of Probiotic Bacteria on Cadmium Toxicity in Rats. Journal  of medicinal  food J Med Food ; 2016; 1–8.
  4. Joseph P.Mechanisms of cadmium carcinogenesis. Toxicological Application Pharmacology.; 2009 ;238:272–279.
  5. Filipič Metka. .Mechanisms of cadmium induced genomic instability. mutation research/fundamental and molecular mechanisms of mutagenesis; 2012; 733(1), 69-77.‏
  6. Rani, A., Kumar, A., Lal, A., & Pant, M. Cellular mechanisms of cadmium-induced toxicity: a review. International journal of environmental health research; 2014 ; 24(4), 378-399.
  7. Naskar, S., Islam, A., Mazumder, U. K., Saha, P., Haldar, P. K., & Gupta, M. In vitro and in vivo antioxidant potential of hydromethanolic extract of Phoenix dactylifera fruits. J Sci Res ;2010; 2(1), 144-157.
  8. Wan, X., Zhu, J., Zhu, Y., Zhu, Y., Ma, X., Zheng, Y & Zhang, T. Rat ovarian follicle bioassay reveals adverse effects of cadmium chloride (CdCl2) exposure on follicle development and oocyte maturation. Toxicology and industrial health, 2010; 26(9), 609-618.
  9. Samuel, J. B., Stanley, J. A., Princess, R. A., Shanthi, P., & Sebastian, M. S.;2011; Gestational cadmium exposure-induced ovotoxicity delays puberty through oxidative stress and impaired steroid hormone levels. Journal of Medical Toxicology, 7(3), 195-204.‏
  10. Alkhedaide, A., Alshehri, Z. S., Sabry, A., Abdel Ghaffar, T., Soliman, M. M., & Attia, H. Protective effect of grape seed extract against cadmium-induced testicular dysfunction. Molecular medicine reports; 2016;: 13(4), 3101-3109.
  11. Mezynska, M., & Brzoska, M. M. Environmental exposure to cadmium-A risk for health of the general population in industrialized countries and preventive strategies, Environmental Science and Pollution Research, ;2018; 25(4), 3211-3232.
  12. Khan, M. A., Khan, S., Khan, A., & Alam, M. Soil contamination with cadmium, consequences and remediation using organic amendments. Science of the Total Environment ;2017; 601, 1591-1605.
  13. Johri, Nikhil, Grégory Jacquillet, and Robert Unwin. "Heavy metal poisoning: the effects of cadmium on the kidney." Biometals 23, no. 5 ;2010; 783-792.
  14. Bekheet, S. H. Comparative effects of repeated administration of cadmium chloride during pregnancy and lactation and selenium protection against cadmium toxicity on some organs in immature rats' offsprings. Biological trace element research; 2011; 144(1-3), 1008-1023.
  15. Nna, V. U., Usman, U. Z., Of utet, E. O., & Owu, D. U. Quercetin exerts preventive, ameliorative and prophylactic effects on cadmium chloride-induced oxidative stress in the uterus and ovaries of female Wistar rats. Food and Chemical Toxicology;2017;  102, 143-155.
  16. Belani, M., Purohit, N., Pillai, P., Gupta, S., & Gupta, S. Modulation of steroidogenic pathway in rat granulosa cells with subclinical Cd exposure and insulin resistance: an impact on female fertility. BioMed research international; 2014.
  17. Veličkov, A., Jančić, N., Điniđić, N., Rančić, I., Bojanić, N. et al .Histological and histochemical characteristics of rat myocardium in cadmium toxicosis. Circulation;2013;  3, 7.
 

Statistics
Article View: 178
PDF Download: 204