Efficacy of Adding Sildenafil Citrate to Clomiphene Citrate as Adjuvant Therapy in Induction of Ovulation | ||||
| Zagazig University Medical Journal | ||||
| Article 8, Volume 30, Issue 8.1, November 2024, Page 3830-3839 PDF (355.88 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2024.262762.3112 | ||||
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| Authors | ||||
Khaled Hassan Mohamed Al-Sadek  1; Youssef Abo Elwan 2; Walid Abdallah1; Ahmed Metwally Mohamed1
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| 1Obstetrics and Gynecology Department, Faculty of Medicine- Zagazig University, Egypt | ||||
| 2Obstetrics and Gynecology Department, Faculty of Medicine- Zagazig University, Egypt. | ||||
| Abstract | ||||
| Background: Patients who had thinner endometrium could be managed using sildenafil citrate, which could be efficient in enhancing endometrial development pregnancy outcomes; clomiphene citrate is first-line treatment for anovulation. The present study aimed for evaluation of effectiveness adding sildenafil citrate to clomiphene citrate as adjunct treatment line for ovulation induction. Subjects and methods: We carried out this randomized controlled clinical trial on 98 cases with primary infertility, 49 cases in every group. From 3rd to 7th day seven, participants in groups A and B took 50 mg CC (Clomid) orally twice daily to induce ovulation. From Day eight until ovulation was triggered, members of group B also received 25 mg of Sildenafil orally once every 12 hours. frequency of pregnancies in two groups was subsequently evaluated. Results: This study revealed a significantly higher follicular size on day 9 in group A (15.56 ± 2.39) vs (13.42 ± 2.25) in group B. A statistically significant difference was revealed in thickness of endometrium between two studied groups in < 7mm and 7 -13mm (p=0.005, 0.013, respectively); in group B (clomiphene with sildenafil), 41 patients (83.7%) had endometrium of 7 to 13 mm. We found that pregnancy rates in group B were 25 cases (51%); 23 patients got pregnant with endometrium thickness from 7-13mm, while only two patients got pregnant with endometrium thickness >13mm, no pregnancy recorded endometrial thickness less than 7mm. Conclusion: Sildenafil citrate could increase pregnancy rates among women who are undergoing ovulation induction using clomiphene citrate by increasing endometrial thickness | ||||
| Keywords | ||||
| Clomiphene Citrate; Sildenafil Citrate; Induction of Ovulation; Infertility | ||||
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