Potency of oil adjuvant inactivated Peste des Petits Ruminants (PPR) vaccine
Hussein, M., Elbagory, G., Khodier, M. (2023). Potency of oil adjuvant inactivated Peste des Petits Ruminants (PPR) vaccine. EKB Journal Management System, 45(2), 173-176. doi: 10.21608/bvmj.2023.247445.1746
Manal Abdelaziz Hussein; Gabr Fikry Elbagory; Mohammad Hassan Khodier. "Potency of oil adjuvant inactivated Peste des Petits Ruminants (PPR) vaccine". EKB Journal Management System, 45, 2, 2023, 173-176. doi: 10.21608/bvmj.2023.247445.1746
Hussein, M., Elbagory, G., Khodier, M. (2023). 'Potency of oil adjuvant inactivated Peste des Petits Ruminants (PPR) vaccine', EKB Journal Management System, 45(2), pp. 173-176. doi: 10.21608/bvmj.2023.247445.1746
Hussein, M., Elbagory, G., Khodier, M. Potency of oil adjuvant inactivated Peste des Petits Ruminants (PPR) vaccine. EKB Journal Management System, 2023; 45(2): 173-176. doi: 10.21608/bvmj.2023.247445.1746

Potency of oil adjuvant inactivated Peste des Petits Ruminants (PPR) vaccine

Benha Veterinary Medical Journal
Volume 45, Issue 2, December 2023, Page 173-176  XML PDF (327.16 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2023.247445.1746
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Authors
Manal Abdelaziz Hussein email 1; Gabr Fikry Elbagoryorcid 2; Mohammad Hassan Khodier3
11 Department of Virology, Faculty of Veterinary Medicine, Benha University, Egypt 2 Veterinary Serum and Vaccine Research Institute (VSVRI), Abbasia, Cairo, Egypt
2Department of Virology, Faculty of Veterinary Medicine, Benha University, Egypt
3Veterinary Serum and Vaccine Research Institute (VSVRI), Abbasia, Cairo, Egypt
Abstract
The Peste des petits ruminant (PPR) is a viral disease caused by a morbilli virus resulted in huge economic losses among sheep and goats. Vaccination is the essential corner stone to control it. Preparation of a safe potent inactivated vaccine could be used during outbreaks or in enharbouring countries free from the disease.  Preparation of PPR virus infected fluid by virus inoculation on Vero cell line followed by virus titration and inactivation by binary ethylene amine and adjuvant by Montanide oil ISA 206 followed by application of quality control testing on the final preparation (freedom from foreign contaminants; safety and potency in susceptible sheep). The prepared inactivated PPR vaccine adjuvanted with Montanide 206 oil is safe and potent able to provide vaccinated sheep with high protective levels of specific immunity. The inactivated PPR vaccine can be used for immunization of sheep protecting them against the virus infection especially those received 2 doses on 2 weeks interval. It is suggested that the obtained immunity may be of long duration remain up to 12 months post vaccination.
Keywords
Pest des petits ruminants; Inactivated vaccine; serum neutralization test; ELIZA
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