Serum ST2 as an early predictor of heart failure in pediatric congenital heart disease. | ||||
| Zagazig University Medical Journal | ||||
| Article 33, Volume 30, Issue 8.1, November 2024, Page 4091-4103 PDF (550.42 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2024.263073.3115 | ||||
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| Authors | ||||
Marwa Lotfy Mohammed Rashad1; Abdulmalik Salih Abdulsalam Shoubar  2; Eman Mahmoud Elmoghazy3; marwa Hussien4
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| 1Pediatrics Department, Faculty of Medicine, Zagazig university | ||||
| 2M.B; B.Ch.; Faculty of Medicine, Tripoli University, Libya | ||||
| 3Professor of Pediatrics, Faculty of Medicine – Zagazig University | ||||
| 4Assistant professor of Biochemistry, Faculty of Medicine – Zagazig University | ||||
| Abstract | ||||
| Background: Heart failure (HF) is a serious consequence that can have varying effects on newborns and children with congenital heart disease (CHD). The soluble isoform of tumor suppression-2 (sST2) has become an interesting promising biomarker of heart failure. The aim of this study was to prove the prognostic role of the soluble suppression of tumorigenicity-2 marker in the early prediction of heart failure in children with congenital heart disease and to correlate its levels with many clinical and echocardiographic issues. Subjects and methods: This case-control study was conducted at the Pediatrics Department, Faculty of Medicine, Zagazig University, on 36 pediatric patients; Patients were allocated into two equal groups; Cases group include 18 patients presented with manifestations of HF complicating CHD and the control group include 18 healthy individuals age & sex matched. Results: The levels of sST were significantly higher in the cases group than in the controls (p<0.001). ROC curve analysis revealed that sST2 cutoff point 30.55 ng/ml; with sensitivity to predict HF in children was 94.4% and with a specificity of 100%. There was a statistically significant positive correlation between sST2 levels and Mitral and Tricuspid E/é, TR, and PASP among the diseased group. In addition, there was a statistically significant negative correlation between the level of sST2 and FS, EF, and Mitral s among the diseased group. Conclusion; Soluble suppression of tumorigenicity-2 could be promising as early predictive and diagnostic biomarker of heart failure in congenital heart disease children. | ||||
| Keywords | ||||
| Congenital heart disease; Heart failure; suppression of tumorigenicity-2 (ST2) | ||||
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