SYNTHESIS OF CERTAIN PYRAZOLO[3,4-d] PYRIMIDINE DERIVATIVES OF POTENTIAL ANTI-INFLAMMATORY ACTIVITY | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 4, Volume 31, Issue 2, December 2008, Pages 197-214 PDF (554.5 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.2008.345095 | ||
| Authors | ||
| Safinaz E. S. Abbas; Hanan H. Georgey; Shimaa M. Abdelrahman; Gamil M. El-Taliawi | ||
| Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Egypt | ||
| Abstract | ||
| The synthesis of twenty nine novel derivatives of pyrazolo[3,4-d]pyrimidines as non acidic nonsteroidal anti-inflammatory drugs has been achieved via reaction of 4-chloro-1-phenylpyrazolo[3,4-d]pyrimidine with different substituents including 4-amino-3-methylphenol, 4-phenylene diamine and 4-acetamidophenol.The anti-inflammatory activity of thirteen representative compounds have been screened compared to indomethacin as a reference drug. The results revealed that all the tested compounds showed anti-inflammatory activity with the exception of 10a. | ||
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