Different Therapeutic Modalities for management of COVID-19 | ||||
| Archives of Pharmaceutical Sciences Ain Shams University | ||||
| Volume 8, Issue 1, June 2024, Page 76-108 PDF (938.27 K) | ||||
| Document Type: Review Article | ||||
| DOI: 10.21608/aps.2024.252694.1150 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Sara S. M. Elmenshawy  1; Mohamed F. A. Abdelsalam2; Tarek R. El Nagdy3; Mohamed A. Elgohary4; Nagwa A. Sabri 5; Amal El-kholy 5
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| 1Department of Clinical Pharmacy, Al-Galaa Military Medical Complex, Cairo, Egypt | ||||
| 2Department of Clinical Pharmacology and Clinical Nutrition, Al-Galaa Military Medical Complex, Cairo, Egypt | ||||
| 3Department of Public Health, Military Medical Academy, Cairo, Egypt | ||||
| 4Department of Tropical Medicine, Military Medical Academy, Cairo, Egypt | ||||
| 5Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt | ||||
| Abstract | ||||
| There is a global health concern caused by the COVID-19 pandemic and need for effective treatments to reduce morbidity and mortality associated with the disease.Aim: The review aims to highlight and compare between different therapeutic modalities for the management of COVID-19. Methods: We conducted a search strategy using medical subject headings (MeSH) and included literature reviews, systematic reviews, and relevant updated publications from 2019 up to October 2023. Results and discussion: The transmission of the virus occurs through direct contact with an infected individual or respiratory droplets expelled through coughing or sneezing. Precautionary measures like isolation, handwashing, mask-wearing, and lockdowns have been implemented, but the need for effective treatment remains paramount. Antiviral, antimicrobial, and immunomodulatory agents have been proposed as potential remedies against COVID-19. The management of symptoms may involve the use of antipyretics or anti-inflammatory medications for fever and mild pain, and oxygen therapy for respiratory distress. In severe cases, mechanical ventilation may be necessary. Conclusion: Hydroxychloroquine and remdesivir have displayed promising outcomes in clinical settings. Tocilizumab, an immunomodulatory agent, has shown reduced mortality rates compared to controls. The combination of bamlanivimab & etesevimab has shown a significant reduction in viral load. Fingolimod, a small molecule modulator, is being studied for its potential to regulate the immune response in severely infected COVID-19 patients. small clinical trial found that the combination of vitamin C and pentoxifylline resulted in lower levels of inflammatory markers. COVID-19 vaccination has shown promising protection against infection, reduced hospitalization rates, and lower mortality rates. | ||||
| Keywords | ||||
| COVID-19; Therapeutic modalities; Antiviral agents; COVID-19 vaccination; Supplements | ||||
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