Prediction Of Thromboembolic Stroke in Non-Valvular Atrial Fibrillation Patients With Low CHA2DS2-VASc Score | ||
| Zagazig University Medical Journal | ||
| Article 17, Volume 30, Issue 1.3, March and April 2024, Pages 139-148 PDF (1.13 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2024.274151.3224 | ||
| Authors | ||
| Moataz A. Elkot* 1; ELsayed M Farag2; Mostafa Mahmoud Mohamed Shams Eldeen3; Hala Gouda Abomandour4 | ||
| 1Lecturer of cardiology faculty of medicine zagazig university | ||
| 2cardiology department , faculty of medicine , zagazig university | ||
| 3MBBCH, Cardiovascular Department, Nasser institute for research and treatment, Cairo,Egypt | ||
| 4A. professor | ||
| Abstract | ||
| Background:Clinical research revealed that thromboembolic events are still a possibility for AF patients with low CHA2DS2-VASc scores Aim:To assess the ability of certain echocardiographic parameters and laboratory biomarkers to predict thromboembolic events in AF patients with low CHA2DS2-VASc score Patients and methods: This is a Case-control study at Cardiology Department, Zagazig University Hospitals and Nasser Institute for Research and Treatment ,was conducted on 159 patients: group 1 included 53 non valvular AF patients having low CHA2DS2-VASc score with Acute Ischemic Stroke (AIS), group 2 included 53 non valvular AF patients having low CHA2DS2-VASc score but without AIS and group 3 included 53 controls without AF or AIS. All groups were investigated by certain echocardiography parameters including left atrial emptying fraction(LAEF) , left atrial volume index (LAVI) , left atrial appendage flow velocity(LAA FV) , mitral annular velocity (E′) and E/e′ ratio , also they were investigated by some laboratory markers including platelet count , red cell distribution width(RDW), platelet distribution width(PDW) , creatinine level , D-dimer level and troponin I. Results:Results: The Receiver Operating Characteristic (ROC) curve analysis showed that several echocardiographic parameters had significant predictive value for stroke ,these parameters were LAVI , LAeF, E/e' ratios, and LAAFV.Also the ROC curve analysis showed that PDW, D-dimer, and troponin had significant predictive value . A novel stroke risk scoring model was developed Conclusion :The novel stroke risk score model may enhance prediction of LAA thrombus in non valvular AF patients with low CHADS-VASc score (0 in male,1 in female) | ||
| Keywords | ||
| Left Atrial Appendage Thrombus; Novel Risk Score; Acute Ischemic Stroke | ||
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