The Relation between serum Kisspeptin level in PCO women and its metabolic and hormonal profiles, Case control study | ||
| Zagazig University Medical Journal | ||
| Article 20, Volume 30, Issue 7, October 2024, Pages 3391-3400 PDF (861.35 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2024.260654.3088 | ||
| Authors | ||
| Amira M.A Gobran1; Nahla Ashraf Zaitoun* 2; Mai Mostafa Zaitoun3; Nermeen Ashraf Zaitoun4 | ||
| 1Lecturer of Physiology department, Faculty of medicine, Zagazig university | ||
| 2lecturer of family medicine, Faculty of medicine Zagazig u | ||
| 3Lecturer of obstetrics and gynecology department, Faculty of medicine, Zagazig university | ||
| 4Lecturer of Physiology Department Faculty of Medicine Zagazig Univerity | ||
| Abstract | ||
| Background: PCO is a metabolic disorder, and its pathogenesis is still unclear, but the changes in the hypothalamic-pituitary-gonadal (HPG) axis are considered one of the main causes in the development of PCO. Kisspeptin is a peptide encoded by the KISS gene that regulates the hypothalamus-pituitary-gonadal (HPG), which may be concerned with the pathogenesis of PCO. Aim: To identify the serum Kisspeptin relation with hormonal and metabolic profiles among normal and PCO women. Methodology: A prospective case-control study was conducted among 64 subjects (32 with PCO and 32 with the control group). The serum Kisspeptin level was measured using enzyme-linked immunosorbent assay (ELISA) and correlated with other hormones such as LH, FSH, DHEA, testosterone, and prolactin. Results: Serum kisspeptin level was significantly higher in the PCO group when compared to the control group. There was a statistically significant positive correlation between kisspeptin and each of HOMA IR, LH, FSH, DHEA, testosterone, and prolactin. Conclusion: The increase in kisspeptin level may play a role in pathogenesis of PCO, and may represent a novel link between metabolic and hormonal disturbance in PCO females since this peptide was correlated with HOMA-IR, LH, FSH, DHEA, testosterone and prolactin. | ||
| Keywords | ||
| Keywords: PCO; Kisspeptin; FSH; LH; Metabolic | ||
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