The Relation between serum Kisspeptin level in PCO women and its metabolic and hormonal profiles, Case control study
Gobran, A., Zaitoun, N., Zaitoun, M., Zaitoun, N. (2024). The Relation between serum Kisspeptin level in PCO women and its metabolic and hormonal profiles, Case control study. EKB Journal Management System, 30(7), 3391-3400. doi: 10.21608/zumj.2024.260654.3088
Amira M.A Gobran; Nahla Ashraf Zaitoun; Mai Mostafa Zaitoun; Nermeen Ashraf Zaitoun. "The Relation between serum Kisspeptin level in PCO women and its metabolic and hormonal profiles, Case control study". EKB Journal Management System, 30, 7, 2024, 3391-3400. doi: 10.21608/zumj.2024.260654.3088
Gobran, A., Zaitoun, N., Zaitoun, M., Zaitoun, N. (2024). 'The Relation between serum Kisspeptin level in PCO women and its metabolic and hormonal profiles, Case control study', EKB Journal Management System, 30(7), pp. 3391-3400. doi: 10.21608/zumj.2024.260654.3088
Gobran, A., Zaitoun, N., Zaitoun, M., Zaitoun, N. The Relation between serum Kisspeptin level in PCO women and its metabolic and hormonal profiles, Case control study. EKB Journal Management System, 2024; 30(7): 3391-3400. doi: 10.21608/zumj.2024.260654.3088

The Relation between serum Kisspeptin level in PCO women and its metabolic and hormonal profiles, Case control study

Zagazig University Medical Journal
Article 20, Volume 30, Issue 7, October 2024, Page 3391-3400  XML PDF (861.35 K)
Document Type: Original Article
DOI: 10.21608/zumj.2024.260654.3088
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Authors
Amira M.A Gobran1; Nahla Ashraf Zaitoun email orcid 2; Mai Mostafa Zaitounorcid 3; Nermeen Ashraf Zaitounorcid 4
1Lecturer of Physiology department, Faculty of medicine, Zagazig university
2lecturer of family medicine, Faculty of medicine Zagazig u
3Lecturer of obstetrics and gynecology department, Faculty of medicine, Zagazig university
4Lecturer of Physiology Department Faculty of Medicine Zagazig Univerity
Abstract
Background: PCO is a metabolic disorder, and its pathogenesis is still unclear, but the changes in the hypothalamic-pituitary-gonadal (HPG) axis are considered one of the main causes in the development of PCO. Kisspeptin is a peptide encoded by the KISS gene that regulates the hypothalamus-pituitary-gonadal (HPG), which may be concerned with the pathogenesis of PCO. Aim: To identify the serum Kisspeptin relation with hormonal and metabolic profiles among normal and PCO women. Methodology: A prospective case-control study was conducted among 64 subjects (32 with PCO and 32 with the control group). The serum Kisspeptin level was measured using enzyme-linked immunosorbent assay (ELISA) and correlated with other hormones such as LH, FSH, DHEA, testosterone, and prolactin. Results: Serum kisspeptin level was significantly higher in the PCO group when compared to the control group. There was a statistically significant positive correlation between kisspeptin and each of HOMA IR, LH, FSH, DHEA, testosterone, and prolactin. Conclusion: The increase in kisspeptin level may play a role in pathogenesis of PCO, and may represent a novel link between metabolic and hormonal disturbance in PCO females since this peptide was correlated with HOMA-IR, LH, FSH, DHEA, testosterone and prolactin.
Keywords
Keywords: PCO; Kisspeptin; FSH; LH; Metabolic
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