Bacterial profile and resistance trends of pathogens implicated in bacterial meningitis: A four years retrospective study | ||
| Microbes and Infectious Diseases | ||
| Article 28, Volume 5, Issue 2, May 2024, Pages 692-703 PDF (819.48 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mid.2024.269589.1797 | ||
| Authors | ||
| Lamia Mohamed EL Moussely1; Nashwa Naguib Omar* 2; Nahla Gamaleldin AbdelHakim Hanafy3; Manal M. Darwish1, 4 | ||
| 1Department of Medical Microbiology and Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||
| 2Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||
| 3Department of Pediatrics, Faculty of Medicine, Modern University for Technology, and Information, Cairo, Egypt. | ||
| 4Department of Microbiology and Immunology October University for Modern Sciences and Arts, Faculty of Pharmacy, Egypt | ||
| Abstract | ||
| Background: Study aims to determine the bacterial profile associated with bacterial meningitis, their antimicrobial resistance pattern providing antimicrobial stewardship guidance and improving the efficacy of empirical treatment. Methods: Four years case-series retrospective study (December 2019- December 2023), of positive CSF cultures in 432 patients of various age groups and departments in Ain Shams University Hospital, Cairo, Egypt were analyzed. Results: Predominance of Gram-negative bacteria constituting 79.1%, while 19.6% were attributed to gram-positive in bacterial meningitis. Notably, Klebsiella pneumoniae (K. pneumoniae) had the highest prevalence at 34%, followed by Acinetobacter species (spp) at 19.6%. Whereas, Streptococcus pneumoniae (S. pneumonia) exhibited a lower prevalence of 1.8%. The age group >16-50 years demonstrated the highest prevalence at 26.6%, followed by infants aged 2 months to <1 year, with a prevalence of 23.3%. Antimicrobial resistance was predominantly against ceftriaxone 89%, and ampicillin 87.9%. Conversely, pathogens exhibited greater sensitivity to tobramycin (46.2%) and gentamicin (43.1%) than other antimicrobials. Multidrug resistance was identified in 53.5% of Gram-negative bacteria. These results highlight Gram-negative bacteria role in meningitis. Conclusion: This study revealed significant changes in meningitis bacterial profiles, highlighting the importance of reinforcing antimicrobial stewardship efforts to effectively combat the evolving landscape of bacterial meningitis. | ||
| Keywords | ||
| Bacterial meningitis; Antimicrobial resistance; Seasonal variation; Age groups; Neonatal meningitis | ||
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