Correlation Between Long non-coding RNA SOX2OT rs9839776 C>T Polymorphism and Unexplained Recurrent Miscarriages | ||
| Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology | ||
| Volume 16, Issue 1, June 2024, Pages 277-295 PDF (546.61 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/eajbsc.2024.346276 | ||
| Authors | ||
| Nermeen M. Abd Ellatif1; Sara H. Agwa2; Neveen A. Ashaat1; Mervat M. Elgendy1 | ||
| 1Zoology Department, Faculty of Science, Ain Shams University, Cairo, Egypt. | ||
| 2Clinical Pathology Department, Molecular Genomics Unit, Medical Ain Shams Research Institute (MASRI), Cairo, Egypt. | ||
| Abstract | ||
| Recurrent miscarriage (RM) is a severe pregnancy complication that results in the loss of two or more spontaneous pregnancies. RM has several complex reasons. Advances in genetics, immunology, and cell biology have strongly connected non-coding RNAs (ncRNAs) to recurrent miscarriages. NcRNAs regulate placental trophoblast cell processes, which affect trophoblast development, migration, and invagination; they also have a role in breast and ovarian cancer. As a result, their abnormal expression may contribute to the progression of RM. Several investigations have found a connection between RM and genetic polymorphisms that regulate cell migration. Variations in the long non-coding RNA (lncRNA) SOX2OT gene have been associated with a variety of cancer-related illnesses, particularly colorectal cancer, breast cancer, and cancer of the digestive tract. According to a recent study, the long non-coding SOX2OT rs9839776 CT raises the risk of RM. In this review, we explain the existing evidence supporting a relationship between the LncRNA SOX2OT rs9839776 polymorphisms and recurrent miscarriages. | ||
| Keywords | ||
| LncRNA SOX2OT; recurrent miscarriage; placental trophoblast; diagnostic biomarker; rs9839776 CT | ||
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