Glutathione's Antioxidant Effects and Its Ability to Shield Mice's Hepatocytes From Damage Caused by Furan | ||
| Food Technology Research Journal | ||
| Volume 3, Issue 2, March 2024, Pages 79-80 PDF (2.14 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ftrj.2024.346574 | ||
| Authors | ||
| Ibrahim M. Ibrahim* ; Hend M. Saleh; Alshaimaa M. Hamouda | ||
| Special Food and Nutrition Department, Food Technology Research Institute, Agricultural Research Center Res. Center, Egypt | ||
| Abstract | ||
| Furan is commonly found in several kinds of heat-treated foods, the existence of furan in food causes public health issues. The current research examines the preventive impact of glutathione on liver, kidney function, and tumor markers against furan-induced injury in mice. Male albino mice were divided into seven groups: a control (G1), G2 (0.5mg furan/kg b.w./day), G3 (1 mg furan/kg b.w./day), G4 (2 mg furan/kg b.w./day), G5 (4 mg furan/kg b.w./day), G6 (2 mg furan/kg b.w./day +500 mg glutathione/kg/day), and G7 (4 mg furan/kg b.w./day +500 mg glutathione/kg/day). At the end of the study, after 8 weeks, the anesthetized and sacrificed were done, and then the different tests were conducted. Results: Furan significantly increased hepatocyte damage in mice, as evidenced by increased activities of aminotransferase (AST) and alanine aminotransferase (ALT) after a 2mg/kg/day dose. Furan promoted oxidative stress due to elevated malondialdehyde levels, occurring at various furan dosages (0.5, 1, 2, and 4mg/kg/day). The study found that pretreatment with glutathione at 500 mg/kg/day reduced AST, ALT, and MDA activities in mice, while furan levels did not negatively impact kidney functions. It should be noted that all levels of furan increased tumor markers [Alpha Fetoprotein (AFP)] compared to the control (3.1 ng/ml), whereas glutathione reduced the level of AFP in groups taking furan at (2 and 4 mg/kg) to range (3.5–3.6 mg/ml) compared to (4.6–4.8 mg/ml) for the same groups taking furan at (2 and 4 mg/kg) without glutathione. Glutathione's protective effects against furan-induced hepatocyte damage may be due to its exceptional capacity to scavenge free radicals. Glutathione, with its strong antioxidant properties, has the potential to be a promising therapeutic and preventive agent for diseases induced by furan compounds. | ||
| Keywords | ||
| Furan; Glutathione; Mice; Liver; Kidney; Tumor Markers; Alpha Fetoprotein | ||
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