Effect of Diabetes Mellitus on Oxidative Stress and Inflammatory Markers in Parkinson's Adult Male Albino Rats | ||
| Minia Journal of Medical Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 24 March 2024 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2024.277030.1691 | ||
| Authors | ||
| Niera Mohamed sameh Mansour* 1; Selim Mahmoud Abdel-Hakim2; Adel Hussein Saad3; Eman Abd Elmonem Elbassuoni2; Wagdy Nashaat Habib3 | ||
| 1Department of medical physiology, faculty of medicine, minia university, minia city, Egypt | ||
| 2physiology department, faculty of medicine, Minia university | ||
| 3Department of Medical Physiology, Faculty of Medicine, Minia University, Minia, Egypt | ||
| Abstract | ||
| Background : Diabetes mellitus (DM) is a chronic metabolic condition defined by persistent hyperglycemia . Parkinsonism is a clinical syndrome with bradykinesia, static tremors, rigidity, and postural instability. Parkinson's disease is a neurological condition that progresses progressively over time. As people age, it becomes more common. Clinical symptoms remain the primary determinant of PD diagnosis. Aim and Objectives: This study aims to detect the effect of diabetes mellitus on model of Parkinson's disease (PD) in adult albino rats. Material and Methods: This study was a prospective controlled experiment done in the laboratory of the Medical Physiology department, under the college of Medicine at Minia University. The experiment involved a collective of 30 rats. Results: The diabetic Parkinson's group exhibited a statistically significant deterioration in Malondialdehyde (MDA) , Total antioxidant capacity (TAC), and Tumor necrosis factor-alpha (TNF-α) compared to the control group (C group), Parkinson's group (P group), and Diabetes Parkinson's group (DP group). Conclusion: Diabetes mellitus has a worsening effect on Parkinson’s disease. | ||
| Keywords | ||
| Diabetes mellitus (DM), Parkinson'; s disease (PD), Malondialdehyde (MDA), Total antioxidant capacity (TAC), Tumor necrosis factor-α (TNF-α ) | ||
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