Effect of Prenatal Exposure to Tartrazine on the Postnatal Development of Gonads in Albino Rats and Protective Role of Sesame Seed Oil | ||
| Egyptian Journal of Histology | ||
| Article 22, Volume 48, Issue 2, June 2025, Pages 728-739 PDF (6.04 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejh.2024.253007.1980 | ||
| Authors | ||
| asmaa sabry bassit* 1; zahraa mohammed ismael2 | ||
| 1anatomy department ,faculty of medicine sohage university,sohage | ||
| 2human anatomy and embryology, faculty of medicine,sohag university,sohag,eygpt | ||
| Abstract | ||
| Introduction: Tartrazine is an artificial dye widely used in foods marketed especially towards children such as candy, ice cream, and soft drinks; it has harmful effects on different body organs and the maturation of male and female reproductive organs. Aim of the Work: The present work aims to study the effect of tartrazine on the postnatal development of gonads and the protective effect of sesame oil. Materials and Methods: This research was done on offspring of adult rats which were divided equally into 3 groups: Group I (Control Group): offspring of mother who received distilled water. Group II (Tartrazine group): offspring of mothers who received TZ (7.5mg/kg/day) via oral gavage from the fifth day of the pregnancy till labor. Group III (sesame oil group offspring of mothers who received TZ (7.5 mg/kg/day) via oral gavage and oral administration of Sesame oil at a dose of 5 ml/kg /day) from the 5th day of pregnancy till labor. Results: In tartrazine treated group the ovary appeared reduced in size, the follicles appeared with destructed granulosa cells and empty oocytes while in the testis the seminiferous tubules showed disorganization of most germinal epithelial cells and vacuolations in Leydig cells. The sesame and tartrazine treated group has a weak role in protection where the ovary appeared with destructed granulosa cells and oocytes while in male rats there was a mild improvement. the immunohistochemical result there was a reaction to caspase -3 in ovarian tissue and to PCNA stain in the testicular tissue. Conclusion: This study discovered that tartrazine leads to disruptions and distortions of ovarian and testicular cells and administration of sesame oil had a weak observable effect. | ||
| Keywords | ||
| Caspase; ovary; PCNA; tartrazine; testis | ||
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