Plasma MicroRNA-133a as a Potential Predictor for Coronary Artery Stenosis Severity | ||
| Zagazig University Medical Journal | ||
| Article 8, Volume 26, Issue 1, January and February 2020, Pages 64-74 PDF (1.09 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2019.13335.1238 | ||
| Authors | ||
| Heba Fawzy El Sayed Turky* 1; Wafaa Abdel Latif Emam1; Sally M Shalaby2; Nader Talaat Kandil3 | ||
| 1Medical Biochemistry & Molecular Biology Department, Faculty of Medicine, Zagazig University | ||
| 2Medical Biochemistry Department-Faculty of Medicine- Zagazig University-Egypt | ||
| 3Cadiology Department , Faculty of Medicine , Zagazig University | ||
| Abstract | ||
| Background: Several scoring systems tried to determine coronary artery stenosis severity to investigate its correlation with laboratory parameters. Aim of the study: To investigate the correlation between the expression levels of circulating miRNA-133a & coronary artery stenosis severity . Patients and Methods: The study was conducted in Medical Biochemistry Department and Cardiology Department - Faculty of Medicine, Zagazig University& Medical Scientific Research Center. It included 72 subjects classified into 2 groups; Group (1): included 18 healthy subjects served as a control. Group (2 included 54 acute coronary syndrome patients. It was subdivided into 3 subgroups each 18 patient: unstable angina , non-ST-segment elevation myocardial infarction and ST-segment elevation myocardial infarction . Plasma miRNA-133a expression level was analyzed by real time PCR. Cardiac Cathetrization was done for showing the severity of stenosis. Results: The present study showed high significant positive correlation between miRNA-133a level and coronary stenosis percentage in unstable angina group (p | ||
| Keywords | ||
| ACS; STEMI; NSTEMI; real time PCR; miRNA 133a | ||
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