Protective effect of Thymoquinone and vitamin E on unilateral testicular torsion/detorsion in rats | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 4, Volume 34, Issue 2, December 2014, Page 187-199 PDF (1.32 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2014.34792 | ||||
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| Author | ||||
Elhussainy Elhussainy 
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| Department of Physiology, Faculty of Medicine, Kafr-Elsheikh University, Egypt | ||||
| Abstract | ||||
| Aim: this work was designed to investigate the effects of Thymoquinone and vitamin E pretreatment after 2 h of unilateral testicular torsion and their possible mechanism of action. Methods: the present study was performed on fifty male albino rats which were divided into five groups. Thymoquinone treated torsion/detorsion group, received pretreatment with Thymoquinone 100 mg/kg intraperitoneally 30 minutes before detorsion. Vitamin E treated torsion/detorsion group); received pretreatment with vit.E 100 mg/kg intraperitoneally 30 minutes before detorsion. Combined Thymoquinone and vit.E treated torsion/detorsion group received pretreatment in a dose of 100 mg/kg for each intraperitoneally 30 minutes before detorsion. Results: thymoquinone and vitamin E pretreatment caused significant decrease of malondialdehyde and nitric oxide levels and significant increase in reduced glutathione and glutathione peroxidase levels compared with untreated torsion/detorsion group. They improved testicular structures as they caused significant decrease in congestion, edema, and damage of seminiferous tubules in the ipsilateral and contralateral testis histologically when compared with torsion/detorsion group. Conclusion: the results suggest that early administration of Thymoquinone and vitamin E might have a protective effect for preventing testicular injury caused by testicular torsion probably through their antioxidant effects | ||||
| Keywords | ||||
| Thymoquinone; Vitamin E; Testicular torsion/detorsion; antioxidants | ||||
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