Role of LncRNA NEAT-1 In Pathogenesis of Psoriasis in Egyptian Patients..
Abd El Aziz, H., Zahra, A., Elamir, A., Mohammed, E. (2024). Role of LncRNA NEAT-1 In Pathogenesis of Psoriasis in Egyptian Patients... EKB Journal Management System, 13(1), 62-74. doi: 10.21608/fumj.2023.237494.1264
Heba Omar Abd El Aziz; Amr Zahra; Azza Elamir; Essam Mohammed. "Role of LncRNA NEAT-1 In Pathogenesis of Psoriasis in Egyptian Patients..". EKB Journal Management System, 13, 1, 2024, 62-74. doi: 10.21608/fumj.2023.237494.1264
Abd El Aziz, H., Zahra, A., Elamir, A., Mohammed, E. (2024). 'Role of LncRNA NEAT-1 In Pathogenesis of Psoriasis in Egyptian Patients..', EKB Journal Management System, 13(1), pp. 62-74. doi: 10.21608/fumj.2023.237494.1264
Abd El Aziz, H., Zahra, A., Elamir, A., Mohammed, E. Role of LncRNA NEAT-1 In Pathogenesis of Psoriasis in Egyptian Patients... EKB Journal Management System, 2024; 13(1): 62-74. doi: 10.21608/fumj.2023.237494.1264

Role of LncRNA NEAT-1 In Pathogenesis of Psoriasis in Egyptian Patients..

Fayoum University Medical Journal
Volume 13, Issue 1, January 2024, Page 62-74  XML PDF (404.25 K)
Document Type: Review Articles
DOI: 10.21608/fumj.2023.237494.1264
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Authors
Heba Omar Abd El Aziz email 1; Amr Zahra2; Azza Elamir3; Essam Mohammed4
1medical biochemistry and molecular biology department, faculty of medicine, fayoum university
2Medical Biochemistry and Molecular Biology department Fayoum university
3Medical Biochemistry and Molecular Biology department Fayoum university
4Medical Biochemistry and Molecular Biology department Fayoum university
Abstract
Introduction:  Psoriasis is a chronic debilitating disease affecting 1-2% of the whole population.
Aim of the study: We aimed to investigate the expression of LncRNA NEAT-1 in psoriasis patients and the possibility of using their serum level as a potential marker for the diagnosis of the disease.
Subjects and Methods: 60 subjects were recruited from Dermatology outpatient clinic for this study and were divided into 2 groups; 40 psoriatic patients and 20 age and sex matched healthy control subjects. LncRNA NEAT-1 expression was detected by quantitative real time polymerase chain reaction “qRT-PCR”
Results: Our results showed a statistically significant increase in the expression of NEAT-1 in the serum of psoriatic patients compared to controls. ROC curve analysis revealed the diagnostic value of NEAT-1 as a predictor in differentiating between cases of psoriasis and controls (p value<0.001, AUC=1).
Conclusions: This study highlights the contribution of LncRNA NEAT-1 in the pathogenesis of psoriasis. The high expression of serum NEAT1 in psoriasis clarified its role as a potential marker for diagnosis and pave the way for the development of a potential therapy.
Keywords
psoriasis; NEAT-1; PCR
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