EFFICACY OF BOTULINUM TOXIN TYPE A IONTOPHORESIS IN THE MASSETER MUSCLE FOR TREATMENT OF MYOFASCIAL PAIN DYSFUNCTION SYNDROME (A RANDOMIZED CONTROLLED CLINICAL STUDY)
Ibrahim, A., Eldibany, R., Melek, L., Abdel-Naby, H. (2025). EFFICACY OF BOTULINUM TOXIN TYPE A IONTOPHORESIS IN THE MASSETER MUSCLE FOR TREATMENT OF MYOFASCIAL PAIN DYSFUNCTION SYNDROME (A RANDOMIZED CONTROLLED CLINICAL STUDY). EKB Journal Management System, 50(2), 60-66. doi: 10.21608/adjalexu.2023.235890.1414
Alaa Ibrahim; Riham Mostafa Eldibany; Lydia Nabil Melek; Hoda Mohamed Abdel-Naby. "EFFICACY OF BOTULINUM TOXIN TYPE A IONTOPHORESIS IN THE MASSETER MUSCLE FOR TREATMENT OF MYOFASCIAL PAIN DYSFUNCTION SYNDROME (A RANDOMIZED CONTROLLED CLINICAL STUDY)". EKB Journal Management System, 50, 2, 2025, 60-66. doi: 10.21608/adjalexu.2023.235890.1414
Ibrahim, A., Eldibany, R., Melek, L., Abdel-Naby, H. (2025). 'EFFICACY OF BOTULINUM TOXIN TYPE A IONTOPHORESIS IN THE MASSETER MUSCLE FOR TREATMENT OF MYOFASCIAL PAIN DYSFUNCTION SYNDROME (A RANDOMIZED CONTROLLED CLINICAL STUDY)', EKB Journal Management System, 50(2), pp. 60-66. doi: 10.21608/adjalexu.2023.235890.1414
Ibrahim, A., Eldibany, R., Melek, L., Abdel-Naby, H. EFFICACY OF BOTULINUM TOXIN TYPE A IONTOPHORESIS IN THE MASSETER MUSCLE FOR TREATMENT OF MYOFASCIAL PAIN DYSFUNCTION SYNDROME (A RANDOMIZED CONTROLLED CLINICAL STUDY). EKB Journal Management System, 2025; 50(2): 60-66. doi: 10.21608/adjalexu.2023.235890.1414

EFFICACY OF BOTULINUM TOXIN TYPE A IONTOPHORESIS IN THE MASSETER MUSCLE FOR TREATMENT OF MYOFASCIAL PAIN DYSFUNCTION SYNDROME (A RANDOMIZED CONTROLLED CLINICAL STUDY)

Alexandria Dental Journal
Article 9, Volume 50, Issue 2, August 2025, Page 60-66  XML PDF (833.65 K)
Document Type: Original Article
DOI: 10.21608/adjalexu.2023.235890.1414
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Authors
Alaa Ibrahim email 1; Riham Mostafa Eldibany2; Lydia Nabil Melek3; Hoda Mohamed Abdel-Naby4
1Bachelor of Dentistry, Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University, Egypt.
2Oral and Maxillofacial Surgery, Faculty of Dentistry, Alexandria University
3Associate Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Alexandria University, Egypt
4physical Medicine, Rheumatology and Rehabilitation Faculty of Medicine, Alexandria University,
Abstract
Background: Masticatory myofascial trigger points (TrPs) represent a major contributor to non-dental orofacial pain. The primary treatment for myofascial TrPs involves intramuscular injections, which can be painful and anxiety-inducing for patients. An alternative, pain-free treatment approach for myofascial pain is iontophoresis.
Aim of this study: This study aimed to assess the efficacy of Botulinum toxin type A (BTX-A) Iontophoresis in managing muscle activity, Visual Analogue Scale (VAS) pain scores, mouth opening range, and Electromyography in individuals diagnosed with myofascial pain dysfunction syndrome (MPDS).
Materials and methods: Twenty-two patients exhibiting symptoms of MPDS in the masseter muscle were included. These patients were randomly divided into two equal groups: the study group (n=11) received BTX-A iontophoresis, while the control group (n=11) received saline iontophoresis as a placebo. Muscle activity at rest and during function was assessed using VAS, the range of mouth opening was measured, and electromyography assessments were conducted. These assessments were performed pre-operatively and during all follow-up visits.
Results: There analysis revealed no significant differences between the two groups at any of the measured timepoints (preoperative, immediate postoperative and 3-month follow-up) concerning pain levels, mouth opening or muscle activity.
Conclusion: The current study revealed no significant differences between the BTX-A and saline groups in the treatment of MPDS by iontophoresis.
Keywords
Myofascial pain; Masseter muscle; trigger points; Botulinum toxin type A; iontophoresis
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