Serum Orexin in Epilepsy: Relation to Cognitive Impairment and Sleep Disorders | ||||
| Zagazig University Medical Journal | ||||
| Article 41, Volume 31, Issue 1.1, January 2025, Page 358-369 PDF (1.8 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2024.279212.3278 | ||||
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| Authors | ||||
Rania yehia helal1; Amany M. AbdAllah2; Sabah Elsayed Fathy  3; Noha Ali Hashim4
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| 1neurology department,faculty of medicine,zagazig university,Zagazig,Egypt | ||||
| 2Department of family medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||||
| 3neurology department, faculty of medicine,zagazig university,zagazig, Eygpt | ||||
| 4Department of Neurology, Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||||
| Abstract | ||||
| Abstract Background: Epilepsy has many co-morbidities which may disturb patient life more than the seizures themselves .Seizures can change brain both structurally and functionally, manifesting as cognitive and neuropsychological disorders. Roughly 30–40% of epileptic patients suffer from cognition changes .Frequent abnormal neuronal discharge, especially status epilepticus, cause oxidative stress leading to disruption of cognitive function. Methods: This case control study was conducted on 158 epileptic patients and158 apparently healthy individuals as a control group, all individuals were exposed to cognitive function testing via The Montreal Cognitive Assessment, sleep quality assessment by Pittsburgh Sleep Quality Index and evaluation of the serum level of orexin was done . Results: 62% of epileptic patients had cognitive impairment; the best cutoff of orexin in prediction of poor cognition among PWE is ≤195 with sensitivity 85.7%, specificity 91.7%. Conclusion: Our data concluded that the prevalence of cognitive impairment in epilepsy is high; serum orexin level could be used as a predictor for cognitive impairment and sleep disorders in epileptics. | ||||
| Keywords | ||||
| Keywords: Orexin; epilepsy; cognitive impairment; sleep disorders | ||||
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