Effect of Ketogenic Diet on the Hypothalamic-Pituitary-Gonadal Axis and Weight loss in Induced Metabolic Syndrome Rat model | ||
| Bulletin of Faculty of Science, Zagazig University | ||
| Article 5, Volume 2024, Issue 1, April 2024, Pages 43-50 PDF (1005.12 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfszu.2023.224632.1289 | ||
| Author | ||
| Hani M Abdelsalam* | ||
| Zoology Department- Zagazig university | ||
| Abstract | ||
| Background: MetS is a metabolic disorder known for abdominal obesity, hyperglycemia, dyslipidemia, and hypertension and is a condition that is commonly induced in lab animals by feeding them a high-fat diet. Lower total testosterone levels have been shown to be corelated to an increased risk of developing metabolic syndrome (MetS). Aim: The purpose of this study was to examine the impact of ketogenic diet (KD) in induced MetS caused by a high-fat diet (HFD) on the hypothalamic-pituitary-gonadal (HPG) axis and testosterone secretion from Leydig cells in male rats. Materials& methods: For 24 weeks, 40 male rats were divided into four groups: those fed a conventional chow diet (the control group), those provided with KD (KD group), group provided with HFD for 8 weeks (the MetS group), and MetS+KD treated group received the diet for 16 weeks. Results: The MetS group had lower serum levels of testosterone, FSH, and LH. KD group and MetS+KD treated group restored the levels of HPG. They also both had decreases in body mass index (BMI), while the Mets group saw significant increases. Conclusion: Our findings suggest that the KD diet is beneficial for metabolic processes and helps with weight gain and dyslipidemia associated with MetS, also helps in restoring a normal regulation of (HPG) and testosterone secretion. | ||
| Keywords | ||
| Ketogenic diet; hypothalamic-pituitary-gonadal axis; metabolic syndrome; high-fat diet; Leydig cells | ||
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