Evaluation of Plasma D-Lactate Level in Preterm Infants with Necrotizing Enterocolitis
El-Farghali, O., Farid, A., Ghanem, D., Metwally, M. (2024). Evaluation of Plasma D-Lactate Level in Preterm Infants with Necrotizing Enterocolitis. EKB Journal Management System, 75(1), 81-88. doi: 10.21608/asmj.2023.241216.1175
Ola G El-Farghali; Ahmed Hamdy Farid; Dina Tharwat Ghanem; Mohamed Hussein Metwally. "Evaluation of Plasma D-Lactate Level in Preterm Infants with Necrotizing Enterocolitis". EKB Journal Management System, 75, 1, 2024, 81-88. doi: 10.21608/asmj.2023.241216.1175
El-Farghali, O., Farid, A., Ghanem, D., Metwally, M. (2024). 'Evaluation of Plasma D-Lactate Level in Preterm Infants with Necrotizing Enterocolitis', EKB Journal Management System, 75(1), pp. 81-88. doi: 10.21608/asmj.2023.241216.1175
El-Farghali, O., Farid, A., Ghanem, D., Metwally, M. Evaluation of Plasma D-Lactate Level in Preterm Infants with Necrotizing Enterocolitis. EKB Journal Management System, 2024; 75(1): 81-88. doi: 10.21608/asmj.2023.241216.1175

Evaluation of Plasma D-Lactate Level in Preterm Infants with Necrotizing Enterocolitis

Ain Shams Medical Journal
Volume 75, Issue 1, March 2024, Pages 81-88    PDF (443.61 K)
Document Type: Original Article
DOI: 10.21608/asmj.2023.241216.1175
Authors
Ola G El-Farghali1; Ahmed Hamdy Farid2; Dina Tharwat Ghanem* 3; Mohamed Hussein Metwally4
1Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
2Pediatrics Department, Faculty of Medicine, Tanta University, Tanta, Egypt
3Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
4Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Abstract
Abstract
Background: Necrotizing enterocolitis (NEC) is a life -threatening condition of the intestines that manifests solely in premature newborns. Early identification of developing NEC is still challenging, as the current radiology and laboratory tests lack sufficient accuracy.
Objective: The current study aimed to assess the role of plasma D-lactate as a diagnostic and prognostic biomarker for NEC.
Methods: The study encompasses 30 preterm neonates diagnosed according to clinical and radiographic criteria as NEC, in addition to 30 preterm growing neonates as matched controls. An assay of plasma D- lactate levels was done by Enzyme-linked immunosorbent assay (ELISA).
Results: The plasma D-lactate levels of NEC patients were significantly higher than to those of the controls (p  0.01). The levels of plasma D lactate also showed a statistically significant increase with worse prognosis of Bell’s stage of the patients (p  0.01). The best cut-off point of D-lactate to identify cases with NEC was > 5.4 μmol/ml with diagnostic sensitivity and specificity of 100%.
Conclusion: Measuring plasma D-lactate levels could be useful as a diagnostic biomarker in the early stage of NEC. Moreover, D-lactate levels can be correlated with the severity of the disease.
Keywords
NEC; neonates; D-lactate; Biomarker; ELISA
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