The Role of Insulin-like Growth Factor 1, Pro-neurotensin and 25-Hydroxy Vitamin D3 in Type 2 Diabetes Mellitus: Metabolic and Pathophysiological links
Abdelsalam, E., Abo-elmatty, D., Mohamed, A., Wahba, A. (2024). The Role of Insulin-like Growth Factor 1, Pro-neurotensin and 25-Hydroxy Vitamin D3 in Type 2 Diabetes Mellitus: Metabolic and Pathophysiological links. EKB Journal Management System, 8(1), 45-62. doi: 10.21608/rpbs.2024.269813.1269
Esraa Atef Abdelsalam; Dina Mohamed Abo-elmatty; Amal Ahmed Mohamed; Alaa Samir Wahba. "The Role of Insulin-like Growth Factor 1, Pro-neurotensin and 25-Hydroxy Vitamin D3 in Type 2 Diabetes Mellitus: Metabolic and Pathophysiological links". EKB Journal Management System, 8, 1, 2024, 45-62. doi: 10.21608/rpbs.2024.269813.1269
Abdelsalam, E., Abo-elmatty, D., Mohamed, A., Wahba, A. (2024). 'The Role of Insulin-like Growth Factor 1, Pro-neurotensin and 25-Hydroxy Vitamin D3 in Type 2 Diabetes Mellitus: Metabolic and Pathophysiological links', EKB Journal Management System, 8(1), pp. 45-62. doi: 10.21608/rpbs.2024.269813.1269
Abdelsalam, E., Abo-elmatty, D., Mohamed, A., Wahba, A. The Role of Insulin-like Growth Factor 1, Pro-neurotensin and 25-Hydroxy Vitamin D3 in Type 2 Diabetes Mellitus: Metabolic and Pathophysiological links. EKB Journal Management System, 2024; 8(1): 45-62. doi: 10.21608/rpbs.2024.269813.1269

The Role of Insulin-like Growth Factor 1, Pro-neurotensin and 25-Hydroxy Vitamin D3 in Type 2 Diabetes Mellitus: Metabolic and Pathophysiological links

Records of Pharmaceutical and Biomedical Sciences
Volume 8, Issue 1, 2024, Page 45-62  XML PDF (948.7 K)
Document Type: Mini-reviews
DOI: 10.21608/rpbs.2024.269813.1269
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Authors
Esraa Atef Abdelsalamorcid 1; Dina Mohamed Abo-elmatty email orcid 2; Amal Ahmed Mohamedorcid 3; Alaa Samir Wahbaorcid 4
1Biochemistry and Molecular Biology, Faculty of Pharmacy, Suez Canal University.
2Biochemistry and Molecular Biology, Faculty of Pharmacy, Suez Canal University and dean Faculty of Pharmacy.
3Biochemistry and molecular biology department, National hepatology and tropical medecine, Cairo, Egypt.
4Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
Abstract
Type 2 diabetes mellitus (T2DM) is a complex disease involving both environmental and genetic contributing factors. T2DM and metabolic syndrome are associated with decreased insulin like growth factor 1 (IGF-1) and vitamin D3. Several studies reported a positive influence of IGF-I on glucose homeostasis exerting insulin-like biological effects. In addition, vitamin D3 has been demonstrated to stimulate insulin secretion from the pancreatic β-cells and modulate β-cell growth and differentiation. Indeed, low vit D3 level has emerged as a risk factor for insulin resistance and T2DM. The relationship between vitamin D deficiency and insulin resistance could develop through inflammation. Pro-neurotensin (pro-NT) is the stable precursor of neurotensin that is secreted by intestinal neuroendocrine cells in response to food ingestion, facilitating lipid absorption with a direct influence on blood glucose control being co-secreted with other gastrointestinal hormones, such as glucagon-like peptide-1 (GLP-1). Elevated pro-NT levels were linked with an increased risk of T2DM and cardiovascular disease and have been reported to predict future development of obesity and diabetes mellitus. Therefore, IGF-I, vitamin D3 and pro-NT can be regarded as promising biomarkers for early diagnosis and treatment of T2DM and also can predict future development of diabetic complications.
Keywords: IGF-I; pro-NT; vitamin D3; T2DM.
Keywords
IGF-I; pro-NT; vitamin D3; T2DM
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