Effect of vitamin D supplementation on gastric emptying in rat model of depression

Hadhod, Shimaa; Gerges, Nawal Khalil; Abd-Elmoula, Asmaa Goda; Soliman, Rania Hassan Mohamed; Abulfadle, Khaled Abdelfattah

doi:10.21608/zumj.2024.287439.3375

	Effect of vitamin D supplementation on gastric emptying in rat model of depression
Zagazig University Medical Journal
Article 4, Volume 31, Issue 5, May 2025, Page 1768-1784 PDF (1.64 MB)
Document Type: Original Article
DOI: 10.21608/zumj.2024.287439.3375
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Authors
Shimaa Hadhod¹; Nawal Khalil Gerges²; Asmaa Goda Abd-Elmoula ³; Rania Hassan Mohamed Soliman ⁴; Khaled Abdelfattah Abulfadle ⁵
¹physiology department , faculty of medicine zagazig university
²physiology department faculty of medicine zagazig university
³(MBBCh. Zagazig University2020) Demonstrator, Physiology department Faculty of medicine, Zagazig University
⁴Department of Human Anatomy and Embryology, Faculty of Medicine, Zagazig University, Egypt
⁵Physiology department, Faculty of medicine, zagazig university, zagazig
Abstract
Background: By 2030, depression is predicted to rank among the top three diseases in terms of burden. Previous research showed controversies about vitamin D's impact on depression and its correlation with altered cognitive function and stomach emptying. We therefore carry out this research to look into this effect. Aim: To investigate the influence of vitamin D on behavior and neurochemical parameters and gastric emptying in a rat model of restraint stress induced depression. Methods: This study was conducted in in the animal unit of the physiology department, faculty of Medicine, Zagazig University on 36 healthy, adult male wistar albino rats. Rats were divided into: group 1 (n=9): Sedentary intact, group 2 (n=9):Depression induced by restraint stress, group 3 (n=9): (depression induced+ prophylactic vitamin D) and group 4 (n=9): (depression induced+ curative vitamin D). Results: Group 2 (restraint induced depression group) showed a significant decrease in gastric empting when compared to that of group 1. Group 3 (preventive vitamin D group) showed a significant increase in gastric empting when compared to that of group 2 and no significance when compared to that of group 1. Conclusion: Vitamin D has a preventative impact against chronic restraint stress-induced behavioral and biochemical abnormalities and relieving somatic symptoms as GIT manifestations.
Keywords
Vitamin D; gastric emptying; rat depression


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