Evaluation of the antibacterial, antibiofilm, and cytotoxic activities of Peltophorum africanum leaf methanolic extract | ||||
| Archives of Pharmaceutical Sciences Ain Shams University | ||||
| Volume 8, Issue 1, June 2024, Page 177-188 PDF (420.93 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/aps.2024.280919.1167 | ||||
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| Authors | ||||
Yomna Elkholy1; Sherif Abdel-All2; Masarra Sakr   1
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| 1Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt | ||||
| 2Department ofPharmacognosy, Faculty of Pharmacy, Al Salam University, Kafr alzayat Algharbia 31611, Egypt | ||||
| Abstract | ||||
| The modern era has used new phytochemical compounds to face the problem of antimicrobial resistance all over the world. The present study aimed to evaluate the antimicrobial and antibiofilm activity of Peltophorum africanum leaf methanolic extract against pathogenic isolates. To achieve this, clinical isolates of Acinetobacter baumannii, Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus were obtained from Al-Demerdash Hospital where their antimicrobial resistance profiles were assessed according to CLSI guidelines using Kirby Bauer disc diffusion method. The calculated minimal inhibitory concentrations (MIC) of the crude extract against the collected isolates ranged between 23 ± 1.1 and 7.8 ± 0.9 with the highest observed activity against MRSA isolates. MIC was determined by the agar well diffusion. Antibiofilm activity was evaluated using the crystal violet method against three strong biofilm producers and showed that the extract exhibited no antibiofilm activity. The paper also investigated its anticancer potential against the human colon cancer cell (Caco-2) line. In conclusion, it can be inferred that; Peltophorum africanum leaf methanolic extract has a good potential to be used in treating infections caused by methicillin-resistant Staphylococcus aureus with probably a high safety profile. | ||||
| Keywords | ||||
| multidrug resistance; coumarins; anti-MRSA; Pseudomonas aeruginosa; Acinetobacter baumannii; herbal remedies | ||||
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