Atypical presentation of Cryoglobulinemia: Case study | ||||
| African Journal of Biological Sciences | ||||
| Volume 20, Issue 1, January 2024, Page 97-102 PDF (250.16 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajbs.2024.354492 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Monira El Waseef1; Mai Farouk1; Nadia Abdelwadod1; shaimaa farouk   2
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| 1Cairo Hospital of Dermatology and Venereology (Al Haud Al Marsoud), Egyptian Ministry of Health and Population, Cairo, Egypt | ||||
| 2Cairo Hospital of Dermatology and Venereology (Al Haud Al Marsoud), Egyptian Ministry of Health and Population, Cairo, Egypt. | ||||
| Abstract | ||||
| Cryoglobulinemia is the presence of immunoglobulins (Igs) that precipitate at low temperatures in serum. cryoglobulinemia is which classified by the components of the cryoprecipitate into 3 types; type I, isolated monoclonal immunoglobulins; type II, a monoclonal component, usually immunoglobulin M (IgM), possessing activity toward polyclonal immunoglobulins, usually immunoglobulin G (IgG); and type III, polyclonal immunoglobulins of more than one isotype. This classification provided a framework for clinical correlations. The vast number of varied conditions associated with the production of cryoglobulins can be roughly classified into three categories: chronic hepatitis C and other infections, autoimmune diseases, and B-cell lymphoid malignancies. Purpura is the main clinical manifestation of cryoglobulinemia being reported in 55% to 100% of patients. The incidence is higher in patients with type II and III cryoglobulinemia rather in those with type I. In this work a 74-year-old female patient complained from atypical presentation of cryoglobulinemic vasculitis confirmed with histopathology, that led to the discovery of relapsing non-Hodgkin lymphoma in apparently healthy individual. | ||||
| Keywords | ||||
| Cryoglobulinemia; Lymphoma; Atypical presentation | ||||
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