Role of Growth Differentiation Factor15 in pediatric cardiac patients | ||||
| SVU-International Journal of Medical Sciences | ||||
| Article 88, Volume 7, Issue 1, January 2024, Page 900-910 PDF (266.56 K) | ||||
| Document Type: Reviews Articles. | ||||
| DOI: 10.21608/svuijm.2022.164871.1416 | ||||
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| Authors | ||||
Khaled Abdalla Abdelbaseer1; Eman Ahmed Abdel mawgood1; Mohamed H. Hassan 2; Mona Hashem Ibrahem  1
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| 1Department of Pediatrics, Faculty of Medicine, South valley University, Qena, Egypt | ||||
| 2Department of Medical Biochemistry , Faculty of Medicine, South Valley University, Qena, Egypt | ||||
| Abstract | ||||
| Background: The most common kind of birth abnormality is a heart problem. When the heart doesn't form properly during pregnancy or birth, it's called a congenital heart defect. CHDs are associated with high rates of mortality and disability. Multiple processes are controlled by the cytokine growth differentiation factor-15 (GDF-15). Because of its continuous overexpression in both CVD and diabetes, GDF-15 is recommended as a biomarker for the existence and severity of both illnesses. In contrast, a large body of research indicates that GDF-15 has a protective role in the regulation of inflammation, endothelial cell function, insulin sensitivity, and weight gain, and is cardioprotective in myocardial infarction (MI). Objectives: Aim of the work is to give highlight on (GDF15) in pediatric cardiac diseases of varies aetiologies. Conclusion: It has been discovered that the cytokine growth differentiation factor-15 (GDF-15) is elevated in a number of clinical states, including hypertension, cardiovascular illness, and oxygen deprivation. GDF-15 is also found to be elevated in HF and PH (pulmonary hypertension). An increased level of GDF-15 is seen in newborns and children with PH-CHD, suggesting its use as a diagnostic biomarker. | ||||
| Keywords | ||||
| Growth Differentiation Factor15; Congenital heart diseases; Pediatric cardiac disease | ||||
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