Synthesis and Antimicrobial Activity of Novel Phthalazine-Aminophosphonate Scaffold Hybrids | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 68, Issue 1, January 2025, Page 165-174 PDF (1.05 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2024.272488.9386 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ibrahim M. Ghanim  ; Ahmed A. El Gokha; Abdel Aleem Hassan Abdel Aleem
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| Departement of Chemistry, Faculty of Science, Menoufia University,Shebin El-Koom, Menoufia, Shebin El Koom-13829, Egypt | ||||
| Abstract | ||||
| The 1-aminophthalazine derivatives (7a-d) were prepared by the reaction of 1-chloro-4-(4`-methoxyphenyl) pthalazine compound 5 with 1, 2-phenylene diamine 6a or 1, 3-phenylene diamine 6b dissolved in DMF while ethylenediamine 6c or 1,4-diaminobutane 6d dissolved in ethanol. The resulting new α-aminophosphonate compounds (10a-f) were produced by combining derivative of 1-aminophthalazine derivatives 7, aldehyde 8 and triphenyl phosphite 9 then LiClO4 as a Lewis acid catalyst was added. The chemical structures of all the produced compounds were determined by IR, 1H-NMR, 13C-NMR, 31P-NMR, and mass spectroscopic methods. The antimicrobial activities of the synthesized compounds were in vitro screened against gram-positive bacteria, gram-negative bacteria and fungi pathogens. The majority of synthesized compounds have moderate to good antimicrobial efficacy. | ||||
| Keywords | ||||
| phthalazine; α-aminophosphonate; antimicrobial activity | ||||
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