Association of Il-6 and Il-10 Genes Polymorphisms with Breast Cancer in Egyptian Women | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 9, Volume 32, Issue 1, June 2012, Pages 125-140 PDF (376.58 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2012.35550 | ||
| Authors | ||
| Abdelnaser Badawy* 1; Hussein Abdalla1; Sabry Mahmoud2; Saad Elshafei3; Dina Eltantawy4 | ||
| 1Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Egypt | ||
| 2General Surgery Department, Faculty of Medicine, Mansoura University, Egypt | ||
| 3Histology Department, Faculty of Medicine, Mansoura University, Egypt | ||
| 4Pathology Department, Faculty of Medicine, Mansoura University, Egypt | ||
| Abstract | ||
| Cytokines are factors that are known to have both tumor-promoting and inhibitory effects on breast cancer growth depending on their relative concentrations and the presence of other modulating factors. Genetic polymorphisms of cytokine-encoding genes are known to predispose to malignant disease. Interleukins -10 and -6 are crucially involved in breast carcinogenesis. The aim of this study is to evaluate the role of IL-6 and IL-10 genes polymorphisms in the pathogenesis of breast cancer in a case – control study of 80 females with breast cancer and 80 healthy females as controls. Patients and controls underwent a clinical examination and finally, one ml blood samples were withdrawn from all cases into tubes containing EDTA as an anticoagulant for analysis of IL-6 and IL-10 genotypes. There were significant association between C allele of the G−174 C promoter single nucleotide polymorphism (SNP) in the IL-6 gene and breast cancer (p = 0.02). But, there were no significant difference in IL-10 1082G→A genotypes frequency in breast cancer when compared with normal individuals (p = 0.99). It's concluded that the CC genotype and C allele of the G−174 C in the IL-6 gene were associated with breast cancer in Egyptian women. | ||
| Keywords | ||
| Cytokines; IL6; IL10; Gene polymorphism; breast cancer | ||
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