Updated review on carbon dots: their synthesis, characterization and analytical applications
Elnaggar, M., Elbardisy, H., El-Yazbi, A., Belal, T. (2024). Updated review on carbon dots: their synthesis, characterization and analytical applications. EKB Journal Management System, 1(2), 42-59. doi: 10.21608/japs.2024.286472.1024
Mai Elnaggar; Hadil Elbardisy; Amira El-Yazbi; Tarek Said Belal. "Updated review on carbon dots: their synthesis, characterization and analytical applications". EKB Journal Management System, 1, 2, 2024, 42-59. doi: 10.21608/japs.2024.286472.1024
Elnaggar, M., Elbardisy, H., El-Yazbi, A., Belal, T. (2024). 'Updated review on carbon dots: their synthesis, characterization and analytical applications', EKB Journal Management System, 1(2), pp. 42-59. doi: 10.21608/japs.2024.286472.1024
Elnaggar, M., Elbardisy, H., El-Yazbi, A., Belal, T. Updated review on carbon dots: their synthesis, characterization and analytical applications. EKB Journal Management System, 2024; 1(2): 42-59. doi: 10.21608/japs.2024.286472.1024

Updated review on carbon dots: their synthesis, characterization and analytical applications

Journal of Advanced Pharmaceutical Sciences
Volume 1, Issue 2, June 2024, Page 42-59  XML PDF (821.27 K)
Document Type: Review Article
DOI: 10.21608/japs.2024.286472.1024
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Authors
Mai Elnaggar1; Hadil Elbardisy2; Amira El-Yazbi email orcid 3; Tarek Said Belal1
1Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
2Pharmaceutical Analysis Department, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt
3Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexandria University
Abstract
One of the most significant advancements in the rapidly expanding field of nanotechnology is colloidal semiconductor nanocrystals, often known as quantum dots. Originally suggested as fluorescent biological markers, they are now discovering significant new applications in analytical chemistry owing to their promising optical, structural, and electrical properties. Carbon dots have attracted a lot of attention lately because of their sustainability, strong biocompatibility, water solubility, low cost of manufacture, and superior chemical stability. Two main methods are used to synthesize carbon dots; the first method is top-down technique, while the second method is bottom-up technique.  Enhancing the photoluminescence, electrical, and structural properties of carbon dots can be achieved via a dependable and versatile method called hetero-atom doping. Carbon dots are used in versatile fields such as; imaging, sensing, cancer treatment, drug quantitation, gene therapy, photodynamic therapy, photothermal therapy, and microorganism eradication. An overview of recent applications of quantum dots from 2011 to 2024 will be presented in this review, which has 50 references.

Highlights
  • Quantum dots nanotechnologically synthesized have unique features and wide applicability.
  • Discussion of versatile applications of quantum dots within analytical techniques and methods.
  • Different synthesis pathways and characterization techniques for C-dots were presented.
  • Various aspects of C-dots applications were thoroughly illustrated with examples.
Keywords
Quantum dots; Carbon dots; Sustainability; Photoluminescence; Therapeutics and Diagnostics
References
  1. Quantum Dots : a True “Particle in a Box” System. [Updated 2015; cited November 20, 2015]. Available from: https://physicsopenlab.org/2015/11/20/quantum-dots-a-true-particle-in-a-box-system/.
  2. Resch-Genger U, Grabolle M, Cavaliere-Jaricot S, Nitschke R, Nann T. Quantum dots versus organic dyes as fluorescent labels. Nat Methods. 2008;5(9):763-75.
  3. Smith AM, Nie S. Chemical analysis and cellular imaging with quantum dots. Analyst. 2004;129(8):672-7.
  4. Frigerio C, Ribeiro DS, Rodrigues SS, Abreu VL, Barbosa JA, Prior JA, et al. Application of quantum dots as analytical tools in automated chemical analysis: a review. Anal Chim Acta. 2012;735:9-22.
  5. Huang S, Li W, Han P, Zhou X, Cheng J, Wen H, et al. Carbon quantum dots: synthesis, properties, and sensing applications as a potential clinical analytical method. Anal Methods. 2019;11(17):2240-58.
  6. Ross S, Wu RS, Wei SC, Ross GM, Chang HT. The analytical and biomedical applications of carbon dots and their future theranostic potential: A review. J Food Drug Anal. 2020;28(4):677-95.
  7. Magdy G, Elmansi H, Belal F, El-Deen AK. Doped Carbon Dots as Promising Fluorescent Nanosensors: Synthesis, Characterization, and Recent Applications. Curr Pharm Des. 2023;29(6):415-44.
  8. Elbardisy HM, Elnaggar MM, Belal TS, Ragab MA, El-Yazbi AF. Green "turn-off" luminescent nanosensors for the sensitive determination of desperately fluorescent antibacterial antiviral agent and its metabolite in various matrices. Sci Rep. 2023;13(1):14131.
  9. Elnaggar MM, El-Yazbi AF, Belal TS, Elbardisy HM. White sustainable luminescent determination of nifuroxazide using nitrogen-sulphur co-doped carbon quantum dots nanosensor in bulk and various pharmaceutical matrices. RSC Adv. 2023;13(43):29830-46.
  10. Lai IP-J, Harroun SG, Chen S-Y, Unnikrishnan B, Li Y-J, Huang C-C. Solid-state synthesis of self-functional carbon quantum dots for detection of bacteria and tumor cells. Sens Actuators B Chem. 2016;228:465-70.
  11. Zhou L, Lin Y, Huang Z, Ren J, Qu X. Carbon nanodots as fluorescence probes for rapid, sensitive, and label-free detection of Hg2+ and biothiols in complex matrices. Chem Commun (Camb). 2012;48(8):1147-9.
  12. Yen YT, Lin YS, Chen TY, Chyueh SC, Chang HT. Carbon dots functionalized papers for high-throughput sensing of 4-chloroethcathinone and its analogues in crime sites. R Soc Open Sci. 2019;6(9):191017.
  13. Tang J, Kong B, Wu H, Xu M, Wang Y, Wang Y, et al. Carbon nanodots featuring efficient FRET for real-time monitoring of drug delivery and two-photon imaging. Adv Mater. 2013;25(45):6569-74.
  14. Jian HJ, Wu RS, Lin TY, Li YJ, Lin HJ, Harroun SG, et al. Super-Cationic Carbon Quantum Dots Synthesized from Spermidine as an Eye Drop Formulation for Topical Treatment of Bacterial Keratitis. ACS Nano. 2017;11(7):6703-16.
  15. Liu L, Feng F, Paau MC, Hu Q, Liu Y, Chen Z, et al. Sensitive determination of kaempferol using carbon dots as a fluorescence probe. Talanta. 2015;144:390-7.
  16. Talaat W, Hassan AF. Optical Nanobiosensing of Stibogluconate in Plasma and Urine Using Green Synthesized Fluorescent Carbon Nanodots. J Appl Spectrosc. 2021;88(2):401-13.
  17. Abd Elhaleem SM, Elsebaei F, Shalan S, Belal F. Utilization of N,S-doped carbon dots as a fluorescent nanosensor for determination of cromolyn based on inner filter effect: application to aqueous humour. Luminescence. 2022;37(5):713-21.
  18. El Sharkasy ME, Tolba MM, Belal F, Walash MI, Aboshabana R. Turn-off fluorescence of S,N-doped carbon dots for determination of two nitro-containing drugs in dosage forms and human plasma. Spectrochim Acta A Mol Biomol Spectrosc. 2023;289:122246.
  19. Guo X, Liu Y, Dong W, Hu Q, Li Y, Shuang S, et al. Azithromycin detection in cells and tablets by N,S co-doped carbon quantum dots. Spectrochim Acta A Mol Biomol Spectrosc. 2021;252:119506.
  20. Zhang Y, Gao Z, Zhang W, Wang W, Chang J, Kai J. Fluorescent carbon dots as nanoprobe for determination of lidocaine hydrochloride. Sens Actuators B Chem. 2018;262:928-37.
  21. Qandeel NA, El-Masry AA, Eid M, Moustafa MA, El-Shaheny R. Fast one-pot microwave-assisted green synthesis of highly fluorescent plant-inspired S,N-self-doped carbon quantum dots as a sensitive probe for the antiviral drug nitazoxanide and hemoglobin. Anal Chim Acta. 2023;1237:340592.
  22. Kailasa SK, Ha S, Baek SH, Phan LMT, Kim S, Kwak K, et al. Tuning of carbon dots emission color for sensing of Fe(3+) ion and bioimaging applications. Mater Sci Eng C Mater Biol Appl. 2019;98:834-42.
  23. Gunjal DB, Gore AH, Naik VM, Pawar SP, Anbhule PV, Shejwal RV, et al. Carbon dots as a dual sensor for the selective determination of d-penicillamine and biological applications. Optical Materials. 2019;88:134-42.
  24. Wang J, Zhang H, Zhao J, Zhang R, Zhao N, Ren H, et al. Simultaneous determination of paracetamol and p-aminophenol using glassy carbon electrode modified with nitrogen- and sulfur- co-doped carbon dots. Mikrochim Acta. 2019;186(11):733.
  25. Zhang X-L, Li X, Li X-T, Gao Y, Feng F, Yang G-J. Electrochemiluminescence sensor for pentoxifylline detection using Au nanoclusters@graphene quantum dots as an amplified electrochemiluminescence luminophore. Sens Actuators B Chem. 2019;282:927-35.
  26. Dehgan-Reyhan S, Najafi M. Defective mesoporous carbon ceramic electrode modified graphene quantum dots as a novel surface-renewable electrode: The application to determination of zolpidem. J Electroanal Chem. 2019;832:241-6.
  27. Liu R, Yang R, Qu C, Mao H, Hu Y, Li J, et al. Synthesis of glycine-functionalized graphene quantum dots as highly sensitive and selective fluorescent sensor of ascorbic acid in human serum. Sens Actuators B Chem. 2017;241:644-51.
  28. Yola ML, Atar N. Development of molecular imprinted sensor including graphitic carbon nitride/N-doped carbon dots composite for novel recognition of epinephrine. Comp Part B Eng. 2019;175:107113.
  29. Kunpatee K, Traipop S, Chailapakul O, Chuanuwatanakul S. Simultaneous determination of ascorbic acid, dopamine, and uric acid using graphene quantum dots/ionic liquid modified screen-printed carbon electrode. Sens Actuators B Chem. 2020;314:128059.
  30. Wu Q, Chen L, Gao J, Dong S, Li H, Di D, et al. Graphene quantum dots-functionalized C(18) hydrophobic/hydrophilic stationary phase for high performance liquid chromatography. Talanta. 2019;194:105-13.
  31. Carrillo-Carrión C, Simonet BM, Valcárcel M, Lendl B. Determination of pesticides by capillary chromatography and SERS detection using a novel Silver-Quantum dots "sponge" nanocomposite. J Chromatogr A. 2012;1225:55-61.
  32. Linkov P, Samokhvalov P, Grokhovsky S, Laronze-Cochard M, Sapi J, Nabiev I. Selection of the optimal chromatography medium for purification of quantum dots and their bioconjugates. Chem Materials. 2020;32(21):9078-89.
  33. Torimoto T, Yamaguchi N, Maeda Y, Akiyoshi K, Kameyama T, Nagai T, et al. Development of plasmonic thin-layer chromatography for size-selective and optical-property-dependent separation of quantum dots. NPG Asia Materials. 2022;14(1):64.
  34. Vicente G, Colón LA. Separation of bioconjugated quantum dots using capillary electrophoresis. Anal Chem. 2008;80(6):1988-94.
  35. Zhao Y, Zhao S, Huang J, Ye F. Quantum dot-enhanced chemiluminescence detection for simultaneous determination of dopamine and epinephrine by capillary electrophoresis. Talanta. 2011;85(5):2650-4.
  36. Lahouidak S, Soriano ML, Salghi R, Zougagh M, Ríos Á. Graphene quantum dots for enhancement of fluorimetric detection coupled to capillary electrophoresis for detection of ofloxacin. Electrophoresis. 2019;40(18-19):2336-41.
  37. Skalickova S, Zitka O, Nejdl L, Krizkova S, Sochor J, Janu L, et al. Study of interaction between metallothionein and CdTe quantum dots. Chromatographia. 2013;76:345-53.
  38. Li J, Wang N, Tran TT, Huang C, Chen L, Yuan L, et al. Electrogenerated chemiluminescence detection of trace level pentachlorophenol using carbon quantum dots. Analyst. 2013;138(7):2038-43.
  39. Magdy G, Abdel Hakiem AF, Belal F, Abdel-Megied AM. Green one-pot synthesis of nitrogen and sulfur co-doped carbon quantum dots as new fluorescent nanosensors for determination of salinomycin and maduramicin in food samples. Food Chem. 2021;343:128539.
  40. Magdy G, Said N, El-Domany RA, Belal F. Nitrogen and sulfur-doped carbon quantum dots as fluorescent nanoprobes for spectrofluorimetric determination of olanzapine and diazepam in biological fluids and dosage forms: application to content uniformity testing. BMC Chem. 2022;16(1):98.
  41. Alossaimi MA, Elmansi H, Alajaji M, Altharawi A, Altamimi AS, Magdy G. A Novel Quantum Dots-Based Fluorescent Sensor for Determination of the Anticancer Dacomitinib: Application to Dosage Forms. Molecules. 2023;28(5):2351.
  42. Magdy G, Al-Enna AA, Belal F, El-Domany RA, Abdel-Megied AM. Application of sulfur and nitrogen doped carbon quantum dots as sensitive fluorescent nanosensors for the determination of saxagliptin and gliclazide. R Soc Open Sci. 2022;9(6):220285.
  43. Magdy G, Ebrahim S, Belal F, El-Domany RA, Abdel-Megied AM. Sulfur and nitrogen co-doped carbon quantum dots as fluorescent probes for the determination of some pharmaceutically-important nitro compounds. Sci Rep. 2023;13(1):5502.
  44. Magdy G, Aboelkassim E, El-Domany RA, Belal F. A novel ultrafast synthesis of N, S-doped carbon quantum dots as a fluorescent nanoprobe for entacapone and clonazepam estimation in tablets and human plasma: Compliance with greenness metrics and content uniformity testing. Sustain Chem Pharm. 2024;38:101488.
  45. Chu T, Liu Y, Gao Y, Zhou C, Huang W, Zheng Y. Copper-nitrogen doped carbon nanosheet-based electrochemical sensors for the detection of luteolin and baicalein. J Mater Sci: Mater Electron. 2024;35(5):340.
  46. Salman BI, Hassan AI, Batakoushy HA, Saraya RE, Abdel-Aal MAA, Al-Harrasi A, et al. Design, Characterization, and Bioanalytical Applications of Green Terbium- and Nitrogen-Doped Carbon Quantum Dots as a Fluorescent Nanoprobe for Omadacycline Analysis. Appl Spectrosc. 2024;78(3):329-39.
  47. Modarres Zahed F, Hatamluyi B, Kalate Bojdi M. A sensitive electrochemical sensor based on graphene quantum dots/hierarchical flower-like gold nanostructures for determination of cytostatic drug flutamide. Materials Sci Eng B. 2024;300:117109.
  48. Rajendran K, Mohamed Nabeel M, Pandian K, Manikandan V, Ganesan S, Lo H-M, et al. Fabrication of silicon quantum dots-methyl viologen nanohybrids: Turn-On-Off-On fluorescence nanoprobe for the detection of d-penicillamine. Microchem J. 2024;197:109803.
  49. Fazl F, Bagher Gholivand M. Application of N-doped carbon quantum dots as a resonance light scattering probe for determination of fluvoxamine. J Photochem Photobiol A Chem. 2024;449:115368.
  50. Sudewi S, Li CH, Chabib L, Rasool A, Arputharaj E, Zulfajri M, et al. Turn-off/turn-on biosensing of tetracycline and ciprofloxacin antibiotics using fluorescent iron oxide quantum dots. Anal Methods. 2024;16(8):1261-71.
  51. Moustafa, R.M, Talaat, W, Youssef, R.M. et al. Carbon dots as fluorescent nanoprobes for assay of some non-fluorophoric nitrogenous compounds of high pharmaceutical interest. Beni-Suef Univ J Basic Appl Sci. 2023; 12: 8.
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