The Effect of Low Dose Capsaicin on Ovarian Histological Structure in Induced Polycystic Ovary Syndrome in Adult Rats | ||
| Egyptian Journal of Histology | ||
| Article 14, Volume 48, Issue 2, June 2025, Pages 595-609 PDF (5.35 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejh.2024.264149.2005 | ||
| Authors | ||
| Alia Khudier* 1; Karim Al-Derawi2; Labeed Al- Saad3 | ||
| 1Anatomy and histology, university of Basrah, Basrah, Iraq | ||
| 2Department of Biology, College of Science , University of Basrah, Basrah, Iraq . | ||
| 3Department of Intelligent Medical System, Collage of Computer Sciences and Information Technology, University of Basrah, Basrah, Iraq. | ||
| Abstract | ||
| Introduction: Capsaicin could contribute effectively in many aspect functions, but its effects of polycystic ovary syndrome (PCOS) have not been examined yet. Aim of the Work: To investigate capsaicin effects on the enhancement of polycystic vary syndrome (PCOS). Materials and Methods: Female rats were examined for the estrus cycles (EC) for about 5 days to constantly ensure its stability. The total number of females used in the current study was 35 animals. They were divided into five groups: (CMC, n=7) carboxymethyl celluose), The (PCOS, n=7), alcohol negative control group (- alcohol, n=7), capsaicin positive control group (+Caps., n=7), and (Letz. + Caps., n=7) group. The generalization of PCOS lasted for 21 days, and the capsaicin treatment continued for 21 days also. All females were weighed and sacrificed to examine the histological changes of the ovary after (PCOS) induction and all treated groups, blood samples collected from all animals to estimate serum LH, FSH, insulin and testosterone levels. Results: Body weight was normal in CMC group, compared to PCOS group while it decreased in alcohol(- control), (+Caps.) and significantly enhanced in (Letz. + Caps.). The level of testosterone was significantly elevated in PCOS group compared to other groups which appeared significantly decreased, the insulin level increased significantly in PCOS group compared to (Letz.+ Caps.). The histological examination of the ovary in PCOS showed multiple cysts (more than five in number), disappeared corpora lutea, and hemorrhage. While in the (Letz. + Caps.) treated group showed enhancement of ovarian histological tissues, the cysts was disappeared, and multiple corpora luteum appeared in the cortex and the huge of blood vessels observed in the medulla when compared with positive control and alcohol administration groups. Conclusion: Capsaicin has significantly enhancing the histological changes of PCOS ovarian that induced in rats. | ||
| Keywords | ||
| Capsaicin; letrozole; polycystic ovary syndrome | ||
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