Comparison between the Effects of Stem Cells and Lepidium Sativum on the Healing of Extraction Socket in Albino Rats (Histological and Immunohistochemical Study) | ||
| Al-Azhar Assiut Dental Journal | ||
| Volume 7, Issue 1, April 2024, Pages 37-48 PDF (5.53 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/aadj.2024.274235.1168 | ||
| Authors | ||
| Khaled ES El-Haddad* 1; Zeinab Mahmoud Abulwafa2; Medhat Ahmed El-Zainy3 | ||
| 1Department of Oral Biology-Faculty of Dentistry -Ain Shams University, Cairo, Egypt. Department of Oral Medical Sciences College of Dentistry, Qassim University, Qassim, Saudi Arabia | ||
| 2Basic and Dental Sciences Department, Faculty of Oral and Dental Medicine, Ahram Canadian University, Cairo, Egypt | ||
| 3Department of Oral Biology, Faculty of Dentistry, Ain Shams University, Cairo, Egypt | ||
| Abstract | ||
| Aim: to compare the bone marrow derived mesenchymal stem cells (BM-MSCs) and Lepidium Sativum (LS) in their potential accelerating actions on the extraction socket healing in albino rats. Subjects and Methods: Forty-five albino rats had their mandibular first molar extracted and divided into 3 groups. Group (1) received no treatment, group (2) received single dose of intravenous BM-MSCs and group (3) received daily oral dose of LS extract till sacrifice. Each group was divided to 3 subgroups A, B and C according to the days from extraction to sacrifice (7, 14 and 30 days). Molar regions were processed for light microscopic examination via Hematoxylin and Eosin (H&E) and anti-osteonectin (ON) immunostain. Bone area fraction in H&E sections and the number of osteoblasts per area in ON sections were statistically analyzed. Results: All groups had proper socket healing, but group 2 had superior histomorphometric values followed by group 3. The least values were of group 1. The studied periods showed ascending bone healing values from day 7 to day 30. All differences between subgroups were statistically significant (p value < 0.05). Conclusion: Both stem cells and Lepidium Sativum have accelerating potential for the extraction socket healing with slight preference of stem cells. | ||
| Keywords | ||
| Stem cells; Lepidium Sativum; Extraction socket; bone marrow. bone healing | ||
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