Impact Of Ketamine Versus Dexmedetomidine Soaked Pharyngeal Packing On Postoperative Sore Throat In Functional Endoscopic Sinus Surgery: A Randomized Controlled Trial | ||||
| Journal of Current Medical Research and Practice | ||||
| Article 6, Volume 9, Issue 2, April 2024, Page 47-56 PDF (318.8 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jcmrp.2024.356693 | ||||
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| Authors | ||||
Amr Mohamed Ahmed Thabet1; Omar Makram Soliman2; Ayman M Osman2; Alaa Gamel Yehia  2; Fatma Al Zahraa Hamed Abdel Hameed3
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| 1Department of of anesthesia, intensive care and pain management, Faculty of Medicine, Assiut University, Egypt, | ||||
| 2Department of of anesthesia, intensive care and pain management, Faculty of Medicine, Assiut University, Egypt | ||||
| 3Department of Anesthesia, intensive care and pain management, South Egypt Cancer Institute, Assiut University, Egypt. | ||||
| Abstract | ||||
| Background: The postoperative sore throat (POST) and post-extubation cough (PEC) frequently follow the insertion of an endotracheal tube in general anesthesia, which makes postoperative morbidity higher. We aimed to assess the efficacy of the dexmedetomidine-soaked pharyngeal pack in alleviating POST versus Ketamine among patients with functional endoscopic sinus surgery (FESS). Methods: One hundred twenty patients were randomized into three groups, each containing 40 patients. Following anesthesia induction and intubation, the placement of pharyngeal packs in either saline (group C), Ketamine (group K), or dexmedetomidine (group D) in the posterior pharyngeal wall was done under clear vision. The primary outcome was the incidence of POST at six hours following surgery. The secondary outcomes were the incidence of POST at 0, 12, and 24 hours, at 0, 30, 60, 90, and 120 minutes, and the Postoperative Nausea and Vomiting (PONV) score at 1, 2, and 6 hours. Results: None of the patients of Group D experienced a POST at 6 hours post-operatively, and this was significantly lower when compared to the ketamine group (67.5%) and control group (87.5%) with a p-value (<0.001). At 6 hours post-operatively, group K experienced considerably fewer POST episodes than group C. Group D showed a lower cough incidence than other groups at 60 minutes. PONV was significantly higher in group K at 2 hours post-operatively. Conclusions: Pharyngeal-soaked dexmedetomidine effectively prevented postoperative airway complications, especially POST, in patients after the FESS procedure. | ||||
| Keywords | ||||
| Cough; Dexmedetomidine; Endoscopic sinus surgery; Ketamine; Sore throat | ||||
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