Analgesic Efficacy And Side Effects Of Three Different Doses Of Intrathecal Ketamine As An Adjuvant To Intrathecal Bupivacaine In Patients Undergoing Knee Arthroscopy: A Randomized Study | ||
| Journal of Current Medical Research and Practice | ||
| Article 7, Volume 9, Issue 2, April 2024, Pages 57-66 PDF (481.63 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jcmrp.2024.356862 | ||
| Authors | ||
| Mostafa Samy Abbas1; walaa hamdy mohamed* 2; Ekram Abdallah Osman1; Ahmed Talat Ahmed1; Magdy Mohamed Mahdy3 | ||
| 1Department of Anaesthesia and Intensive Care, Faculty of Medicine, Assiut University, Assiut, Egypt. | ||
| 2Department of Anaesthesia and IntensiveCare,faculity of medicine,Assiut Univerisity,Assiut,Egypt. | ||
| 3Department of Anaesthesia and Intensive Care, Faculty of Medicine, Assiut University, Assiut, Egypt | ||
| Abstract | ||
| Abstract Background: The co-administration of intrathecal ketamine and bupivacaine resulted in a substantial improvement in the time elapsed before the initial request for analgesics. A range of doses, spanning from 0.05 to 0.7 mg/kg, has been utilized in previous studies. We aimed to compare three doses to ascertain the optimal dosage that delivers the most effective pain relief while minimizing potential side effects. Methods: One hundred and five patients aged 18-70 years, with a body mass index (BMI) of 20-30 kg/m2 and planned for knee arthroscopy were randomly allocated to receive intrathecal heavy bupivacaine 0.5% in addition to intrathecal ketamine at a dose of either 0.1 mg/kg (n = 35), 0.2 mg/kg (n = 35), or 0.3 mg/kg (n = 35). Our primary outcome was the time elapsed to first rescue analgesia. Results: All groups exhibited comparable time intervals until the first rescue analgesic was requested (11.4 ± 3.99 vs 11.2 ± 4.65 vs 11.63 ± 5.11, p = 0.93). The groups examined also demonstrated similar numeric rating scale (NRS) scores during the 6th, 12th, and 24th postoperative hours. However, a statistically significant difference was observed among the groups regarding the incidence of confusion and dizziness (p = 0.001), with a higher occurrence in the 0.2 and 0.3 mg groups compared to the 0.1 mg group. Conclusion: Based on our findings, it can be inferred that an intrathecal ketamine dose of 0.1 mg/kg exhibits analgesic efficacy comparable to higher doses while having the fewest side effects | ||
| Keywords | ||
| Intrathecal ketamine; Bupivacaine; Knee arthroscopy; Analgesia | ||
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