Analgesic Efficacy And Side Effects Of Three Different Doses Of Intrathecal Ketamine As An Adjuvant To Intrathecal Bupivacaine In Patients Undergoing Knee Arthroscopy: A Randomized Study
Abbas, M., mohamed, W., Osman, E., Ahmed, A., Mahdy, M. (2024). Analgesic Efficacy And Side Effects Of Three Different Doses Of Intrathecal Ketamine As An Adjuvant To Intrathecal Bupivacaine In Patients Undergoing Knee Arthroscopy: A Randomized Study. EKB Journal Management System, 9(2), 57-66. doi: 10.21608/jcmrp.2024.356862
Mostafa Samy Abbas; walaa hamdy mohamed; Ekram Abdallah Osman; Ahmed Talat Ahmed; Magdy Mohamed Mahdy. "Analgesic Efficacy And Side Effects Of Three Different Doses Of Intrathecal Ketamine As An Adjuvant To Intrathecal Bupivacaine In Patients Undergoing Knee Arthroscopy: A Randomized Study". EKB Journal Management System, 9, 2, 2024, 57-66. doi: 10.21608/jcmrp.2024.356862
Abbas, M., mohamed, W., Osman, E., Ahmed, A., Mahdy, M. (2024). 'Analgesic Efficacy And Side Effects Of Three Different Doses Of Intrathecal Ketamine As An Adjuvant To Intrathecal Bupivacaine In Patients Undergoing Knee Arthroscopy: A Randomized Study', EKB Journal Management System, 9(2), pp. 57-66. doi: 10.21608/jcmrp.2024.356862
Abbas, M., mohamed, W., Osman, E., Ahmed, A., Mahdy, M. Analgesic Efficacy And Side Effects Of Three Different Doses Of Intrathecal Ketamine As An Adjuvant To Intrathecal Bupivacaine In Patients Undergoing Knee Arthroscopy: A Randomized Study. EKB Journal Management System, 2024; 9(2): 57-66. doi: 10.21608/jcmrp.2024.356862

Analgesic Efficacy And Side Effects Of Three Different Doses Of Intrathecal Ketamine As An Adjuvant To Intrathecal Bupivacaine In Patients Undergoing Knee Arthroscopy: A Randomized Study

Journal of Current Medical Research and Practice
Article 7, Volume 9, Issue 2, April 2024, Page 57-66  XML PDF (481.63 K)
Document Type: Original Article
DOI: 10.21608/jcmrp.2024.356862
View on SCiNiTO View on SCiNiTO
Authors
Mostafa Samy Abbas1; walaa hamdy mohamed email orcid 2; Ekram Abdallah Osman1; Ahmed Talat Ahmedorcid 1; Magdy Mohamed Mahdyorcid 3
1Department of Anaesthesia and Intensive Care, Faculty of Medicine, Assiut University, Assiut, Egypt.
2Department of Anaesthesia and IntensiveCare,faculity of medicine,Assiut Univerisity,Assiut,Egypt.
3Department of Anaesthesia and Intensive Care, Faculty of Medicine, Assiut University, Assiut, Egypt
Abstract
Abstract
Background: The co-administration of intrathecal ketamine and bupivacaine resulted in a substantial improvement in the time elapsed before the initial request for analgesics. A range of doses, spanning from 0.05 to 0.7 mg/kg, has been utilized in previous studies. We aimed to compare three doses to ascertain the optimal dosage that delivers the most effective pain relief while minimizing potential side effects.
Methods: One hundred and five patients aged 18-70 years, with a body mass index (BMI) of 20-30 kg/m2 and planned for knee arthroscopy were randomly allocated to receive intrathecal heavy bupivacaine 0.5% in addition to intrathecal ketamine at a dose of either 0.1 mg/kg (n = 35), 0.2 mg/kg (n = 35), or 0.3 mg/kg (n = 35). Our primary outcome was the time elapsed to first rescue analgesia.
Results: All groups exhibited comparable time intervals until the first rescue analgesic was requested (11.4 ± 3.99 vs 11.2 ± 4.65 vs 11.63 ± 5.11, p = 0.93). The groups examined also demonstrated similar numeric rating scale (NRS) scores during the 6th, 12th, and 24th postoperative hours. However, a statistically significant difference was observed among the groups regarding the incidence of confusion and dizziness (p = 0.001), with a higher occurrence in the 0.2 and 0.3 mg groups compared to the 0.1 mg group.
Conclusion: Based on our findings, it can be inferred that an intrathecal ketamine dose of 0.1 mg/kg exhibits analgesic efficacy comparable to higher doses while having the fewest side effects
Keywords
Intrathecal ketamine; Bupivacaine; Knee arthroscopy; Analgesia
Statistics
Article View: 145
PDF Download: 112